Thyroid Peroxidase (TPO) (Active) Protein

Name: Thyroid Peroxidase (TPO)

Synonyms: MSA, TPX, TDH2A, TPO, msa, tpx, xtpo, LOC100218312

Protein Type: Recombinant

Biological Activity: Active

Source: Escherichia Coli (E. coli)

Origin (Gene): Human

Application: Western Blotting (WB), ELISA, Functional Studies (Func)

Catalog no.: ABIN413831

Additional Information

Gene ID: 7173

UniProt: P07202

Endotoxin Level: <0.1 ng/µg

Description: TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
Synonyms: Human TPO, TPO, h-TPO, rh-TPO, recombinant human TPO, recombinant TPO, TPO,

Characteristics: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found <1 ng/ml, corresponding to a specific activity of >1 x 10⁶ IU/mg.

Application Details

Handling Advice: Centrifuge the vial prior to opening.

Purity: >98% by SDS-PAGE and HPLC analyses Endotoxin level is <0.1 ng per μ g of TPO.

Buffer: Lyophilized with no additives

Storage: -20°C.
Stability: 12 months

Research Area: Enzymes

Restrictions: For Research Use only

Publications

Product: Kinzfogl, Hangoc, Broxmeyer: "Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells." in: Blood, Vol. 118, Issue 3, pp. 565-75, 2011 (PubMed).