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Thyroid Peroxidase (TPO) (Active) Protein

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Protein Name
(31), (9), (7), (2)
Escherichia coli (E. coli)
(28), (4), (2), (2), (2), (2), (2), (1), (1), (1)
Protein Type Recombinant
Biological Activity Active
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
Pubmed 1 reference available
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Quantity 10 μg
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Characteristics Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found <1 ng/mL, corresponding to a specific activity of >1 x 10⁶ IU/mg.
Purity ≥98 %
Endotoxin Level <0.1 ng/μg
Background TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
Synonyms: Human TPO, TPO, h-TPO, rh-TPO, recombinant human TPO, recombinant TPO, TPO,
Gene ID 7173
UniProt P07202
Application Notes Optimal working dilution should be determined by the investigator.

physical form description: Lyophilized with no additives

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitution in purified H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use. For long term storage it is recommended to add a carrier protein (0.1 % HAS or BSA).
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Kinzfogl, Hangoc, Broxmeyer: "Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells." in: Blood, Vol. 118, Issue 3, pp. 565-75, 2011 (PubMed).

Catalog No. ABIN413831
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