Thyroid Peroxidase (TPO) (Active) Protein

Details for Product No. ABIN413832
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Protein Name
Synonyms MSA, TPX, TDH2A, TPO, msa, tpx, xtpo, LOC100218312
Origin
Human
(35), (14), (8), (1)
Source
Escherichia coli (E. coli)
(34), (6), (4), (3), (2), (1), (1), (1)
Protein Type Recombinant
Biological Activity Active
Application
Western Blotting (WB), ELISA, Functional Studies (Func)
Pubmed 1 reference available
Catalog no. ABIN413832
Quantity 1 mg
Price
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Characteristics Biological activity: less than 1 ng/mL The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found less than 1 ng/mL, corresponding to a specific activity of more than1 x 10^6 IU/mg.
Purity > 98 % by SDS-PAGE and HPLC analysis
Endotoxin Level < 0.1 ng/μg
Alternative Name TPO
Background TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
Synonyms: Human TPO, TPO, h-TPO, rh-TPO, recombinant human TPO, recombinant TPO, TPO, Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, mL, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO.
Gene ID 7173
UniProt P07202
Research Area Enzymes
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitution in purified H2O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use. For long term storage it is recommended to add a carrier protein (0.1 % HAS or BSA).
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Kinzfogl, Hangoc, Broxmeyer: "Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells." in: Blood, Vol. 118, Issue 3, pp. 565-75, 2011 (PubMed).

Hosts (34), (6), (4), (3), (2), (1), (1), (1)
Reactivities (35), (14), (8), (1)
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