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Thyroid Peroxidase (TPO) (Active) Protein
|Synonyms||MSA, TPX, TDH2A, TPO, msa, tpx, xtpo, LOC100218312|
Escherichia Coli (E. coli)
Western Blotting (WB), ELISA, Functional Studies (Func)
|1 reference available|
|Quantity||1 mg (Variants)|
|Price||4,290.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Reconstitution||Reconstitution in purified H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. For long term storage it is recommended to add a carrier protein (0.1% HAS or BSA).|
|Endotoxin Level||<0.1 ng/μg|
TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
Synonyms: Human TPO, TPO, h-TPO, rh-TPO, recombinant human TPO, recombinant TPO, TPO, Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO.
|Characteristics||Biological activity: <1 ng/mL The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found <1 ng/mL, corresponding to a specific activity of >1 x 10⁶ IU/mg.|
|Handling Advice||Centrifuge the vial prior to opening.|
|Purity||>98% by SDS-PAGE and HPLC analyses Endotoxin level is <0.1 ng per μ g of TPO.|
|Buffer||Lyophilized with no additives|
|Expiry Date||12 months|
|Restrictions||For Research Use only|
Kinzfogl, Hangoc, Broxmeyer: "Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells." in: Blood, Vol. 118, Issue 3, pp. 565-75, 2011 (PubMed).
|Hosts||Escherichia Coli (E. coli) (17), Yeast (4), Sf-9 cells (3), CHO (2), Baculovirus/Sf9 (1)|
|Reactivities||Human (18), Mouse (Murine) (8), Rat (Rattus) (6), Pig (Porcine) (1)|