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Thyroid Peroxidase (TPO) (Active) Protein

Details for Product No. ABIN413833, Supplier: Log in to see
Protein Name
  • TPO
  • msa
  • tpx
  • xtpo
  • LOC100218312
  • MSA
  • TDH2A
  • TPX
Origin
Human
30
11
7
2
Source
Escherichia coli (E. coli)
28
4
3
2
2
2
2
1
1
1
Protein Type
Recombinant
Biological Activity
Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Characteristics Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found <1 ng/mL, corresponding to a specific activity of >1 x 10⁶ IU/mg.
Purity ≥98 %
Endotoxin Level <0.1 ng/μg
Background TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
Synonyms: Human TPO, TPO, h-TPO, rh-TPO, recombinant human TPO, recombinant TPO, TPO,
Gene ID 7173
UniProt P07202
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Comment

physical form description: Lyophilized with no additives

Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitution in purified H₂O to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use. For long term storage it is recommended to add a carrier protein (0.1 % HAS or BSA).
Handling Advice Centrifuge the vial prior to opening.
Storage -20 °C
Expiry Date 12 months
Product cited in: Kinzfogl, Hangoc, Broxmeyer: "Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells." in: Blood, Vol. 118, Issue 3, pp. 565-75, 2011 (PubMed).