ACVA Protein (AA 311-426)

Catalog No. ABIN4369364

Product Details

Target: ACVA (Activin A (ACVA))

Protein Type: Recombinant

Biological Activity: Active

Protein Characteristics: AA 311-426

Origin: Human

Source: HEK-293 Cells

Brand: ActiveMax®

Sequence: AA 311-426

Characteristics: This protein carries no "tag". The protein has a calculated MW of 13 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).

Purity: >95 % as determined by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 0.1 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.056 % TFA in 60 % ACN

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution

References

Basu, Bhattacharya, Ray, Mukhopadhyay, Chatterjee, Roy: "Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A." in: Molecular cancer, Vol. 14, pp. 162, (2015) (PubMed).

Target Details

Target: ACVA (Activin A (ACVA))

Alternative Name: Activin A /INHBA (ACVA Products)

Synonyms: inhibin beta A subunit Protein, Inhba Protein

Background: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100 % amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.

Molecular Weight: 13.0 kDa

Pathways: Hormone Transport, Peptide Hormone Metabolism