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MAN1B1 Protein (AA 106-699) (His tag)

MAN1B1 Origin: Human Host: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Catalog No. ABIN4370760
  • Target See all MAN1B1 Proteins
    MAN1B1 (Mannosidase, Alpha, Class 1B, Member 1 (MAN1B1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 106-699
    Origin
    • 4
    • 2
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    • 1
    • 1
    Human Cells
    Purification tag / Conjugate
    This MAN1B1 protein is labelled with His tag.
    Purpose
    Recombinant Human ER α-1,2-Mannosidase/MAN1B1 (C-6His)
    Sequence
    DHWKALAFRL EEEQKMRPEI AGLKPANPPV LPAPQKADTD PENLPEISSQ KTQRHIQRGP PHLQIRPPSQ DLKDGTQEEA TKRQEAPVDP RPEGDPQRTV ISWRGAVIEP EQGTELPSRR AEVPTKPPLP PARTQGTPVH LNYRQKGVID VFLHAWKGYR KFAWGHDELK PVSRSFSEWF GLGLTLIDAL DTMWILGLRK EFEEARKWVS KKLHFEKDVD VNLFESTIRI LGGLLSAYHL SGDSLFLRKA EDFGNRLMPA FRTPSKIPYS DVNIGTGVAH PPRWTSDSTV AEVTSIQLEF RELSRLTGDK KFQEAVEKVT QHIHGLSGKK DGLVPMFINT HSGLFTHLGV FTLGARADSY YEYLLKQWIQ GGKQETQLLE DYVEAIEGVR THLLRHSEPS KLTFVGELAH GRFSAKMDHL VCFLPGTLAL GVYHGLPASH MELAQELMET CYQMNRQMET GLSPEIVHFN LYPQPGRRDV EVKPADRHNL LRPETVESLF YLYRVTGDRK YQDWGWEILQ SFSRFTRVPS GGYSSINNVQ DPQKPEPRDK MESFFLGETL KYLFLLFSDD PNLLSLDAYV FNTEAHPLPI WTPAVDHHHH HH
    Characteristics
    Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-alpha-Mannosidase/MAN1B1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Asp106-Ala699) of Human MAN1B1 fused with a polyhistidine tag at the C-terminus.
    Purity
    > 95 % as determined by reducing SDS-PAGE.
    Sterility
    0.2 μm filtered
    Endotoxin Level
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product MAN1B1 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Supplied as a 0.2 μm filtered solution of 50 mM TrisHCL,10 mM reduced Glutathione, pH 8.0.
    Handling Advice
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Storage
    -80 °C
    Storage Comment
    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    MAN1B1 (Mannosidase, Alpha, Class 1B, Member 1 (MAN1B1))
    Alternative Name
    MAN1B1 (MAN1B1 Products)
    Synonyms
    erman1 Protein, mana-er Protein, MAN1B1 Protein, ERMAN1 Protein, MANA-ER Protein, MRT15 Protein, E430019H13Rik Protein, ERMan1 Protein, Gm108 Protein, RGD1563595 Protein, mannosidase alpha class 1B member 1 Protein, mannosidase, alpha, class 1B, member 1 L homeolog Protein, endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase Protein, mannosidase, alpha, class 1B, member 1 Protein, MAN1B1 Protein, man1b1.L Protein, LOC480667 Protein, man1b1 Protein, Man1b1 Protein
    Sub Type
    Fusionprotein
    Background
    Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-alpha-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
    Alternative Names: Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase, ER Alpha-1,2-Mannosidase, ER Mannosidase 1, ERMan1, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, Mannosidase Alpha Class 1B Member 1, MAN1B1
    Molecular Weight
    68.7 kDa
    UniProt
    Q9UKM7
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