Kallikrein Protein

Name: Kallikrein

Synonyms: klkr, kallikrein, KLK1E2, hpk

Origin (Gene): Human

Catalog no.: ABIN491202

Additional Information

Gene ID: 3816

Swiss-Prot: P06870

Format: Frozen

Description: Kallikrein, Human Plasma. Activation of Prekallikrein with Factor alpha-XIIa produces the enzymatically active Kallikrein. Kallikrein is a serine protease which consists of a heavy chain (Mr 52kD) and light chains (Mr either 36 or 33 kD) linked by disulfide bridges. Kallikrein possesses enzymatic activity toward Factor XII, HK, Plasminogen, Factors XI, IX, and VII, prorenin and the complement system. After activation, the activating enzyme Factor XIIa is removed by affinity chromatography. Human Kallikrein purity is >95% by SDS-PAGE and shows complete reduction upon incubation with 2-mercaptoethanol. Prepared from plasma found negative by FDA accepted methods for Anti-HIV1/2, Anti-HTLV I & II, HBsAg, Anti-HCV, Syphilis, HBC Ab, HIV-1 p24 Ag or HIV-1 RNA, HCV RNA and HBV RNA. Donors are screened for CJD (Creutzfeldt-Jakob Disease).

Molecular Weight: 86000

Application Details

Concentration: Sample concentration 2.0 mg/ml, concentration varies by lot

Purity: >95% by SDS-PAGE

Purification: Chromatographically purified

Buffer: 0.004M Sodium Acetate, 0.15M NaCl, pH 5.3

Storage: Store at -70°C

Research Area: Coagulation