Prorenin Protein

Details for Product No. ABIN491434, Supplier: Log in to see
Protein Name
  • renin
  • REN
Origin
Human
2
2
2
1
Source
HEK
4
Protein Type
Native
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Characteristics Recombinantly produced in HEK cell culture as untagged native form prorenin and purified by affinity chromatography. Fully activatable to renin by catalytic amounts of trypsin. Prorenin is a glycosylated aspartic protease that consists of 2 homologous lobes and is the precursor of renin. Prorenin exhibits a low level of enzymatic activity relative to renin which is generated from prorenin by proteolytic cleavage of the first ~43 amino acids at the N-terminus. This so called prosegment appears to block the full enzymatic potential of the active site (1). Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced by the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme primarily within the capillaries of the lungs. It has been reported that the levels of circulating prorenin (but not renin) are increased in diabetic subjects(2)
Purification Chromatographically purified
Purity > 95 % by SDS-PAGE
Gene ID 5972
UniProt Q99665
Restrictions For Research Use only
Format Frozen
Concentration 1.0 mg/mL
Buffer 10 mM Tris, 0.1M NaCl, pH 8.0
Storage -80 °C
Supplier Images
Western Blotting (WB) image for Prorenin Protein (ABIN491434) Prorenin protein
Product cited in: Yisireyili, Saito, Abudureyimu, Adelibieke, Ng, Nishijima, Takeshita, Murohara, Niwa: "Indoxyl sulfate-induced activation of (pro)renin receptor promotes cell proliferation and tissue factor expression in vascular smooth muscle cells." in: PLoS ONE, Vol. 9, Issue 10, pp. e109268, 2014 (PubMed).