Haptoglobin (HP) Protein

Details for Product No. ABIN491578, Supplier: Log in to see
Protein Name
  • HP
  • wu:fb64e01
  • BP
  • HP2ALPHA2
  • HPA1S
  • HP-1
  • HPR
  • Zonulin
  • haptoglobin
  • haptoglobin-like
  • HP
  • hp
  • Hp
  • LOC100067869
Origin
Human
32
7
5
4
4
4
3
2
1
1
1
1
1
1
1
Source
Human
23
13
12
5
2
1
1
1
1
1
1
1
Protein Type
Native
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Characteristics An acute-phase plasma protein found in human plasma at 100-300 mg per 100 ml. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes. Hp 1-1 is the most common, and the most effective in binding free hemoglobin. Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype. Prepared from plasma shown to be non reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. Molecular Weights by phenotype - Hp 1-1: 86,000, Hp 2-1: 200,000, Hp 2-2: 400,000.
Purification Chromatographically purified
Purity > 95 % by SDS-PAGE
Gene ID 3240
UniProt P00738
Research Area Cardiovascular, Serum/Plasma Proteins
Pathways Transition Metal Ion Homeostasis
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add deionized water to original volume, aliquot and freeze unused portion.
Buffer Salt free
Storage -80 °C
Supplier Images
SDS-PAGE (SDS) image for Haptoglobin (HP) Protein (ABIN491578) Haptoglobin (HP) protein
Product cited in: Almeida, Souza, Leonardo, Costa, Werneck, Covas, Costa, Conran: "Acute hemolytic vascular inflammatory processes are prevented by nitric oxide replacement or a single dose of hydroxyurea." in: Blood, Vol. 126, Issue 6, pp. 711-20, 2015 (PubMed).

Zapotoczna, Heilbronner, Speziale, Foster: "Iron-regulated surface determinant (Isd) proteins of Staphylococcus lugdunensis." in: Journal of bacteriology, Vol. 194, Issue 23, pp. 6453-67, 2012 (PubMed).