Plasminogen (PLG) Protein

Details for Product No. ABIN491590
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Protein Name
Synonyms wu:fb70e09, PLG, LPA, plg, Ab1-346, AI649309, Pg
Origin
Human
(31), (15), (10), (10), (6), (6), (2), (2), (1)
Source
Human
(16), (12), (6), (6), (6), (4), (3), (2), (2), (1), (1), (1)
Protein Type Native
Pubmed 1 reference available
Quantity 1 mL
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Catalog No. ABIN491590
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Characteristics We have immobilized human Lys plasmin on agarose resin by coupling of primary amines. Plasmin retains catalytic activity when coupled and may be used to efficiently activate single-chain tPA and uPA to the two-chain form (1). It may also be used to convert plasminogen from its native Glu form to the Lys form by removing the first 77 amino acids. References: 1. Wallen, P. et al. (1982) Biochim. Biophys. Acta 719:318-328.
Concentration: 1.0 mg/mL coupled
Purification Chromatographically purified
Purity > 95 % by SDS-PAGE
Alternative Name Plasmin
Gene ID 5340
UniProt P00747
Restrictions For Research Use only
Format Liquid
Buffer 0.1M HEPES, 0.1M NaCl, 0.02 % Sodium Azide, pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Komissarov, Florova, Idell: "Effects of extracellular DNA on plasminogen activation and fibrinolysis." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 41949-62, 2011 (PubMed). Further details: Drs. Komissarov, Florova and Idell at the Univ. of Texas HSC used this reagent to investigate effects of DNA on the fibrinolysis pathway. DNA binding increases plasminogen activation by tPA/uPA as well as PAI-1 inhibition of tPA/uPA.

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