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Plasminogen (PLG) Protein

Details for Product No. ABIN491590, Supplier: Login to see New
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Protein Name
Synonyms wu:fb70e09, PLG, LPA, plg, Ab1-346, AI649309, Pg
(34), (12), (7), (4), (4), (4), (2), (2), (1), (1), (1)
(19), (18), (8), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Protein Type Native
Pubmed 1 reference available
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Quantity 1 mL
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Availability Will be delivered in 2 to 3 Business Days
Characteristics We have immobilized human Lys plasmin on agarose resin by coupling of primary amines. Plasmin retains catalytic activity when coupled and may be used to efficiently activate single-chain tPA and uPA to the two-chain form (1). It may also be used to convert plasminogen from its native Glu form to the Lys form by removing the first 77 amino acids. References: 1. Wallen, P. et al. (1982) Biochim. Biophys. Acta 719:318-328.
Concentration: 1.0 mg/mL coupled
Purification Chromatographically purified
Purity > 95 % by SDS-PAGE
Gene ID 5340
UniProt P00747
Pathways Complement System
Restrictions For Research Use only
Format Liquid
Buffer 0.1M HEPES, 0.1M NaCl, 0.02 % Sodium Azide, pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Komissarov, Florova, Idell: "Effects of extracellular DNA on plasminogen activation and fibrinolysis." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 41949-62, 2011 (PubMed). Further details: Drs. Komissarov, Florova and Idell at the Univ. of Texas HSC used this reagent to investigate effects of DNA on the fibrinolysis pathway. DNA binding increases plasminogen activation by tPA/uPA as well as PAI-1 inhibition of tPA/uPA.

Catalog No. ABIN491590
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