You are viewing an incomplete version of our website. Please click to reload the website as full version.

Plasminogen (PLG) Protein

Details for Product No. ABIN491590, Supplier: Log in to see
Protein Name
  • wu:fb70e09
  • PLG
  • LPA
  • plg
  • Ab1-346
  • AI649309
  • Pg
Origin
Human
35
13
6
4
4
4
2
2
1
1
1
Source
Human
20
20
7
2
2
2
2
2
2
1
1
1
Protein Type
Native
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Characteristics We have immobilized human Lys plasmin on agarose resin by coupling of primary amines. Plasmin retains catalytic activity when coupled and may be used to efficiently activate single-chain tPA and uPA to the two-chain form (1). It may also be used to convert plasminogen from its native Glu form to the Lys form by removing the first 77 amino acids. References: 1. Wallen, P. et al. (1982) Biochim. Biophys. Acta 719:318-328.
Concentration: 1.0 mg/mL coupled
Purification Chromatographically purified
Purity > 95 % by SDS-PAGE
Gene ID 5340
UniProt P00747
Pathways Complement System
Restrictions For Research Use only
Format Liquid
Buffer 0.1M HEPES, 0.1M NaCl, 0.02 % Sodium Azide, pH 7.4
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Komissarov, Florova, Idell: "Effects of extracellular DNA on plasminogen activation and fibrinolysis." in: The Journal of biological chemistry, Vol. 286, Issue 49, pp. 41949-62, 2011 (PubMed). Further details: Drs. Komissarov, Florova and Idell at the Univ. of Texas HSC used this reagent to investigate effects of DNA on the fibrinolysis pathway. DNA binding increases plasminogen activation by tPA/uPA as well as PAI-1 inhibition of tPA/uPA.