CHMP5 Protein (AA 1-219, full length) (His-SUMO Tag)

Catalog No. ABIN4975685

Product Details

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Protein Type: Recombinant

Protein Characteristics: full length, AA 1-219

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This CHMP5 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MNRLFGKAKP KAPPPSLTDC IGTVDSRAES IDKKISRLDA ELVKYKDQIK KMREGPAKNM VKQKALRVLK QKRMYEQQRD NLAQQSFNME QANYTIQSLK DTKTTVDAMK LGVKEMKKAY KQVKIDQIED LQDQLEDMME DANEIQEALS RSYGTPELDE DDLEAELDAL GDELLADEDS SYLDEAASAP AIPEGVPTDT KNKDGVLVDE FGLPQIPAS

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))

Alternative Name: CHMP5 (CHMP5 Products)

Synonyms: SNF7DC2 Protein, cgi-34 Protein, hspc177 Protein, pnas-2 Protein, vps60 Protein, chmp5 Protein, zgc:64125 Protein, C9orf83 Protein, HSPC177 Protein, PNAS-2 Protein, Vps60 Protein, 2210412K09Rik Protein, AW545668 Protein, RGD1305968 Protein, charged multivesicular body protein 5 S homeolog Protein, charged multivesicular body protein 5b Protein, charged multivesicular body protein 5 Protein, charged multivesicular body protein 5 L homeolog Protein, chromatin modifying protein 5 Protein, chmp5.S Protein, chmp5b Protein, CHMP5 Protein, chmp5.L Protein, chmp5 Protein, Chmp5 Protein

Background: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting mbrane of the endosome and mostly are delivered to lysosomes enabling degradation of mbrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating mbrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent mbrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or mbrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Molecular Weight: 40.6 kDa

UniProt: Q9NZZ3