GNL3L Protein (AA 1-582, full length) (His-SUMO Tag)
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- Target See all GNL3L Proteins
- GNL3L (Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-582, full length
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This GNL3L protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MMKLRHKNKK PGEGSKGHKK ISWPYPQPAK QNGKKATSKV PSAPHFVHPN DHANREAELK KKWVEEMREK QQAAREQERQ KRRTIESYCQ DVLRRQEEFE HKEEVLQELN MFPQLDDEAT RKAYYKEFRK VVEYSDVILE VLDARDPLGC RCFQMEEAVL RAQGNKKLVL VLNKIDLVPK EVVEKWLDYL RNELPTVAFK ASTQHQVKNL NRCSVPVDQA SESLLKSKAC FGAENLMRVL GNYCRLGEVR THIRVGVVGL PNVGKSSLIN SLKRSRACSV GAVPGITKFM QEVYLDKFIR LLDAPGIVPG PNSEVGTILR NCVHVQKLAD PVTPVETILQ RCNLEEISNY YGVSGFQTTE HFLTAVAHRL GKKKKGGLYS QEQAAKAVLA DWVSGKISFY IPPPATHTLP THLSAEIVKE MTEVFDIEDT EQANEDTMEC LATGESDELL GDTDPLEMEI KLLHSPMTKI ADAIENKTTV YKIGDLTGYC TNPNRHQMGW AKRNVDHRPK SNSMVDVCSV DRRSVLQRIM ETDPLQQGQA LASALKNKKK MQKRADKIAS KLSDSMMSAL DLSGNADDGV GD
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product GNL3L Protein
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Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L) (AA 1-582) protein (GST tag)
GNL3L Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L) (AA 1-582) protein (Strep Tag)Crystallography grade GNL3L Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L) (AA 1-577) protein (Strep Tag)Crystallography grade GNL3L Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L) (AA 1-582), (full length) protein (His-SUMO Tag)GNL3L Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- GNL3L (Guanine Nucleotide Binding Protein-Like 3 (Nucleolar)-Like (GNL3L))
- Alternative Name
- GNL3L (GNL3L Products)
- Synonyms
- SI:zK13A21.8 Protein, flj10613 Protein, flj10613l Protein, si:dkey-13a21.8 Protein, zgc:110536 Protein, BC020354 Protein, guanine nucleotide binding protein-like 3 (nucleolar)-like Protein, guanine nucleotide binding protein-like 3 (nucleolar)-like S homeolog Protein, G protein nucleolar 3 like Protein, gnl3l Protein, gnl3l.S Protein, GNL3L Protein, Gnl3l Protein
- Background
- Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
- Molecular Weight
- 81.53 kDa
- UniProt
- Q9NVN8
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