BRCC3 Protein (AA 2-316) (His-SUMO Tag)
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- Target See all BRCC3 Proteins
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-316
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This BRCC3 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- AVQVVQAVQA VHLESDAFLV CLNHALSTEK EEVMGLCIGE LNDDTRSDSK FAYTGTEMRT VAEKVDAVRI VHIHSVIILR RSDKRKDRVE ISPEQLSAAS TEAERLAELT GRPMRVVGWY HSHPHITVWP SHVDVRTQAM YQMMDQGFVG LIFSCFIEDK NTKTGRVLYT CFQSIQAQKS SESLHGPRDF WSSSQHISIE GQKEEERYER IEIPIHIVPH VTIGKVCLES AVELPKILCQ EEQDAYRRIH SLTHLDSVTK IHNGSVFTKN LCSQMSAVSG PLLQWLEDRL EQNQQHLQEL QQEKEELMQE LSSLE
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product BRCC3 Protein
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BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 1-316) protein (GST tag)
BRCC3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 2-316) protein (His tag)Crystallography grade BRCC3 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 2-291) protein (His tag)Crystallography grade BRCC3 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) (AA 2-316) protein (His-SUMO Tag)BRCC3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
- Alternative Name
- BRCC3 (BRCC3 Products)
- Synonyms
- CXorf53 Protein, BRCC3 Protein, xtp1 Protein, brcc3 Protein, BRCC36 Protein, brcc36 Protein, C6.1A Protein, BRCA1/BRCA2-containing complex subunit 3 Protein, DEP domain containing 1B Protein, BRCA1/BRCA2-containing complex, subunit 3 Protein, BRCA1/BRCA2-containing complex subunit 3 L homeolog Protein, BRCC3 Protein, depdc1b Protein, brcc3 Protein, Brcc3 Protein, brcc3.L Protein
- Background
- Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically roves 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex
- Molecular Weight
- 51.9 kDa
- UniProt
- P46736
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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