ETHE1 Protein (AA 8-254) (His-SUMO Tag)
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- Target See all ETHE1 Proteins
- ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 8-254
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This ETHE1 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- VARRQLSQRG GSGAPILLRQ MFEPVSCTFT YLLGDRESRE AVLIDPVLET APRDAQLIKE LGLRLLYAVN THCHADHITG SGLLRSLLPG CQSVISRLSG AQADLHIEDG DSIRFGRFAL ETRASPGHTP GCVTFVLNDH SMAFTGDALL IRGCGRTDFQ QGCAKTLYHS VHEKIFTLPG DCLIYPAHDY HGFTVSTVEE ERTLNPRLTL SCEEFVKIMG NLNLPKPQQI DFAVPANMRC GVQTPTA
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product ETHE1 Protein
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Ethylmalonic Encephalopathy 1 (ETHE1) (AA 13-254) protein (His tag)
ETHE1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Ethylmalonic Encephalopathy 1 (ETHE1) (AA 1-254) protein (GST tag)ETHE1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Ethylmalonic Encephalopathy 1 (ETHE1) (AA 155-254) protein (GST tag)ETHE1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Ethylmalonic Encephalopathy 1 (ETHE1) (AA 8-254) protein (His tag)Crystallography grade ETHE1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Ethylmalonic Encephalopathy 1 (ETHE1) (AA 8-254) protein (His tag)Crystallography grade ETHE1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Ethylmalonic Encephalopathy 1 (ETHE1) (AA 8-254) protein (His-SUMO Tag)ETHE1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Ethylmalonic Encephalopathy 1 (ETHE1) protein (Myc-DYKDDDDK Tag)ETHE1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- ETHE1 (Ethylmalonic Encephalopathy 1 (ETHE1))
- Alternative Name
- ETHE1 (ETHE1 Products)
- Synonyms
- zgc:85680 Protein, HSCO Protein, YF13H12 Protein, 0610025L15Rik Protein, Hsco Protein, ETHE1, persulfide dioxygenase Protein, ethylmalonic encephalopathy 1 Protein, Ethe1 Protein, ethe1 Protein, ETHE1 Protein
- Background
- Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H2S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H2S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus .
- Molecular Weight
- 43.08 kDa
- UniProt
- O95571
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