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EYA2 Protein (AA 1-514, Isoform 2) (His-SUMO Tag)

EYA2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Catalog No. ABIN4976210
  • Target See all EYA2 Proteins
    EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
    Protein Type
    Recombinant
    Protein Characteristics
    Isoform 2, AA 1-514
    Origin
    • 4
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This EYA2 protein is labelled with His-SUMO Tag.
    Application
    SDS-PAGE (SDS)
    Sequence
    MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSFS TSPTGQSPYT YQMHGTTGFY QGGNGLGNAA GFGSVHQDYP SYPGFPQSQY PQYYGSSYNP PYVPASSICP SPLSTSTYVL QEASHNVPNQ SSESLAGEYN THNGPSTPAK EGDTDRPHRA SDGKLRGRSK RSSDPSPAGD NEIERVFVWD LDETIIIFHS LLTGTFASRY GKDTTTSVRI GLMMEEMIFN LADTHLFFND LEDCDQIHVD DVSSDDNGQD LSTYNFSADG FHSSAPAANL CLGSGVHGGV DWMRKLAFRY RRVKEMYNTY KNNVGGLIGT PKRETWLQLR AELEALTDLW LTHSLKALNL INSRPNCVNV LVTTTQLIPA LAKVLLYGLG SVFPIENIYS ATKTGKESCF ERIMQRFGRK AVYVVIGDGV EEEQGAKKHN MPFWRISCHA DLEALRHALE LEYL
    Purification
    SDS-PAGE
    Purity
    > 90 %
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  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.1-2 mg/mL
    Buffer
    20 mM Tris-HCl based buffer, pH 8.0
    Storage
    -80 °C,4 °C,-20 °C
    Storage Comment
    Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Target
    EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
    Alternative Name
    EYA2 (EYA2 Products)
    Synonyms
    EYA2 Protein, zgc:92279 Protein, eab1 Protein, Eab1 Protein, EAB1 Protein, EYA transcriptional coactivator and phosphatase 2 Protein, EYA2 Protein, eya2 Protein, Eya2 Protein
    Background
    Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1.
    Molecular Weight
    72.7 kDa
    UniProt
    O00167
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