EYA2 Protein (AA 1-514, Isoform 2) (His-SUMO Tag)
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- Target See all EYA2 Proteins
- EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
- Protein Type
- Recombinant
- Protein Characteristics
- Isoform 2, AA 1-514
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This EYA2 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSFS TSPTGQSPYT YQMHGTTGFY QGGNGLGNAA GFGSVHQDYP SYPGFPQSQY PQYYGSSYNP PYVPASSICP SPLSTSTYVL QEASHNVPNQ SSESLAGEYN THNGPSTPAK EGDTDRPHRA SDGKLRGRSK RSSDPSPAGD NEIERVFVWD LDETIIIFHS LLTGTFASRY GKDTTTSVRI GLMMEEMIFN LADTHLFFND LEDCDQIHVD DVSSDDNGQD LSTYNFSADG FHSSAPAANL CLGSGVHGGV DWMRKLAFRY RRVKEMYNTY KNNVGGLIGT PKRETWLQLR AELEALTDLW LTHSLKALNL INSRPNCVNV LVTTTQLIPA LAKVLLYGLG SVFPIENIYS ATKTGKESCF ERIMQRFGRK AVYVVIGDGV EEEQGAKKHN MPFWRISCHA DLEALRHALE LEYL
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product EYA2 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))
- Alternative Name
- EYA2 (EYA2 Products)
- Synonyms
- EYA2 Protein, zgc:92279 Protein, eab1 Protein, Eab1 Protein, EAB1 Protein, EYA transcriptional coactivator and phosphatase 2 Protein, EYA2 Protein, eya2 Protein, Eya2 Protein
- Background
- Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1.
- Molecular Weight
- 72.7 kDa
- UniProt
- O00167
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