MBNL1 Protein (AA 1-382) (His-SUMO Tag)
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- Target See all MBNL1 Proteins
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-382
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MBNL1 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MAVSVTPIRD TKWLTLEVCR EFQRGTCSRP DTECKFAHPS KSCQVENGRV IACFDSLKGR CSRENCKYLH PPPHLKTQLE INGRNNLIQQ KNMAMLAQQM QLANAMMPGA PLQPVPMFSV APSLATNASA AAFNPYLGPV SPSLVPAEIL PTAPMLVTGN PGVPVPAAAA AAAQKLMRTD RLEVCREYQR GNCNRGENDC RFAHPADSTM IDTNDNTVTV CMDYIKGRCS REKCKYFHPP AHLQAKIKAA QYQVNQAAAA QAAATAAAMG IPQAVLPPLP KRPALEKTNG ATAVFNTGIF QYQQALANMQ LQQHTAFLPP GSILCMTPAT SVVPMVHGAT PATVSAATTS ATSVPFAATA TANQIPIISA EHLTSHKYVT QM
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product MBNL1 Protein
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Muscleblind-like Protein 1 (MBNL1) (Transcript Variant 6) (Active) protein (Myc-DYKDDDDK Tag)
MBNL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
Muscleblind-like Protein 1 (MBNL1) (AA 1-343) protein (GST tag)MBNL1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Muscleblind-like Protein 1 (MBNL1) (AA 1-382) protein (GST tag)MBNL1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Muscleblind-like Protein 1 (MBNL1) (AA 1-388) protein (Strep Tag)Crystallography grade MBNL1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Muscleblind-like Protein 1 (MBNL1) (AA 1-341) protein (Strep Tag)Crystallography grade MBNL1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Muscleblind-like Protein 1 (MBNL1) (AA 1-382) protein (His-SUMO Tag)MBNL1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Muscleblind-like Protein 1 (MBNL1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)MBNL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Muscleblind-like Protein 1 (MBNL1) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)MBNL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Muscleblind-like Protein 1 (MBNL1) (Transcript Variant 5) protein (Myc-DYKDDDDK Tag)MBNL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Muscleblind-like Protein 1 (MBNL1) (Transcript Variant 7) protein (Myc-DYKDDDDK Tag)MBNL1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- MBNL1 (Muscleblind-like Protein 1 (MBNL1))
- Alternative Name
- MBNL1 (MBNL1 Products)
- Synonyms
- MBNL1 Protein, zgc:153954 Protein, Mbnl Protein, mKIAA0428 Protein, EXP Protein, EXP35 Protein, EXP40 Protein, EXP42 Protein, MBNL Protein, muscleblind like splicing regulator 1 Protein, muscleblind-like splicing regulator 1 Protein, muscleblind like splicing factor 1 Protein, MBNL1 Protein, mbnl1 Protein, Mbnl1 Protein
- Background
- Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the st-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assbly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
- Molecular Weight
- 57 kDa
- UniProt
- Q9NR56
- Pathways
- Ribonucleoprotein Complex Subunit Organization
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