COBRA1 Protein (AA 8-199, partial) (GST tag)
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- Target See all COBRA1 Proteins
- COBRA1 (Cofactor of BRCA1 (COBRA1))
- Protein Type
- Recombinant
- Protein Characteristics
- partial, AA 8-199
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This COBRA1 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- LGVANGEDLK ETLTNCTEPL KAIEQFQTEN GVLLPSLQSA LPFLDLHGTP RLEFHQSVFD ELRDKLLERV SAIASEGKAE ERYKKLEDLL EKSFSLVKMP SLQPVVMCVM KHLPKVPEKK LKLVMADKEL YRACAVEVKR QIWQDNQALF GDEVSPLLKQ YILEKESALF STELSVLHNF FSPSPKTRRQ GE
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product COBRA1 Protein
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Cofactor of BRCA1 (COBRA1) (AA 1-475) protein (GST tag)
COBRA1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Cofactor of BRCA1 (COBRA1) (AA 1-580) protein (Strep Tag)Crystallography grade COBRA1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Cofactor of BRCA1 (COBRA1) (AA 1-580) protein (Strep Tag)Crystallography grade COBRA1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Cofactor of BRCA1 (COBRA1) (AA 8-199), (partial) protein (GST tag)COBRA1 Origin: Human Host: Escherichia coli (E. coli) Recombinant 90 % ELISA
Cofactor of BRCA1 (COBRA1) protein (Myc-DYKDDDDK Tag)COBRA1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- COBRA1 (Cofactor of BRCA1 (COBRA1))
- Alternative Name
- NELFB (COBRA1 Products)
- Synonyms
- LOC100219583 Protein, COBRA1 Protein, NELF-B Protein, bZ1O1.4 Protein, cobra1 Protein, cobra2 Protein, fe01e12 Protein, wu:fe01e12 Protein, zgc:55628 Protein, MGC131073 Protein, Cobra1 Protein, RGD1307832 Protein, A730008L03Rik Protein, AB041607 Protein, AI663983 Protein, Nelf-b Protein, cofactor of BRCA1 Protein, negative elongation factor complex member B Protein, negative elongation factor complex member B L homeolog Protein, LOC100219583 Protein, NELFB Protein, nelfb Protein, nelfb.L Protein, Nelfb Protein
- Background
- Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.
- Molecular Weight
- 49.2 kDa
- UniProt
- Q8WX92
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