FOXP1 Protein (AA 1-114, partial) (GST tag)

Catalog No. ABIN4976382

Product Details

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Protein Type: Recombinant

Protein Characteristics: partial, AA 1-114

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This FOXP1 protein is labelled with GST tag.

Application: SDS-PAGE (SDS)

Sequence: MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD LAHAQQQQQQ WHLINHQPSR SPSSWLKRLI SSPWELEVLQ VPLWGAVAET KMSGPVCQPN PSPF

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Alternative Name: FOXP1 (FOXP1 Products)

Synonyms: 12CC4 Protein, QRF1 Protein, hFKH1B Protein, 3110052D19Rik Protein, 4932443N09Rik Protein, AI461938 Protein, AW494214 Protein, foxp1 Protein, im:7139058 Protein, wu:fc83a06 Protein, FOXP1 Protein, MGC145686 Protein, 12cc4 Protein, fkh1b Protein, hspc215 Protein, qrf1 Protein, xlfoxp1 Protein, im:7146611 Protein, wu:fb97f01 Protein, zgc:154010 Protein, forkhead box P1 Protein, forkhead box P1b Protein, forkhead box P1 S homeolog Protein, forkhead box P1a Protein, FOXP1 Protein, Foxp1 Protein, foxp1b Protein, foxp1 Protein, foxp1.S Protein, foxp1a Protein

Background: Transcriptional repressor . Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential . Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in bryonic st cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle st cell quiescence, the function probably involves regulation of FGF18 . Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis . Binds to CSF1R promoter elents and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes ses to involve NCOR2 as corepressor . Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization ses to implicate suppression of SA5B . Can negatively regulate androgen receptor signaling .

Molecular Weight: 39.6 kDa

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response