PABP Protein (AA 1-370, partial) (His-SUMO Tag)

Catalog No. ABIN4976565

Product Details

Target: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Protein Type: Recombinant

Protein Characteristics: AA 1-370, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This PABP protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MNPSAPSYPM ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDMITRR SLGYAYVNFQ QPADAERALD TMNFDVIKGK PVRIMWSQRD PSLRKSGVGN IFIKNLDKSI DNKALYDTFS AFGNILSCKV VCDENGSKGY GFVHFETQEA AERAIEKMNG MLLNDRKVFV GRFKSRKERE AELGARAKEF TNVYIKNFGE DMDDERLKDL FGKFGPALSV KVMTDESGKS KGFGFVSFER HEDAQKAVDE MNGKELNGKQ IYVGRAQKKV ERQTELKRKF EQMKQDRITR YQGVNLYVKN LDDGIDDERL RKEFSPFGTI TSAKVMMEGG RSKGFGFVCF SSPEEATKAV TEMNGRIVAT KPLYVALAQR

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: PABP (PABPC1) (Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1))

Alternative Name: PABP1 (PABPC1 Products)

Synonyms: PAB1 Protein, PABP Protein, PABP1 Protein, PABPC2 Protein, PABPL1 Protein, Pabp1 Protein, PabpI Protein, Pabpl1 Protein, ePAB Protein, Pabp Protein, pab1 Protein, pabp Protein, pabp1 Protein, pabpc1 Protein, pabpc2 Protein, PABPC1 Protein, wu:fb16a02 Protein, wu:fi19b08 Protein, wu:fj12d09 Protein, wu:fj61f06 Protein, zgc:109879 Protein, zgc:77608 Protein, poly(A) binding protein cytoplasmic 1 Protein, poly(A) binding protein, cytoplasmic 1 Protein, poly(A) binding protein, cytoplasmic 1 S homeolog Protein, poly(A) binding protein cytoplasmic 1 like Protein, poly(A) binding protein, cytoplasmic 1 L homeolog Protein, poly(A) binding protein, cytoplasmic 1a Protein, poly A binding protein, cytoplasmic 1 b Protein, PABPC1 Protein, Pabpc1 Protein, pabpc1.S Protein, pabpc1 Protein, PABPC1L Protein, pabpc1.L Protein, pabpc1a Protein, pabpc1b Protein

Background: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing prature stop codons, for the recognition of prature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.

Molecular Weight: 57.8 kDa

UniProt: P11940

Pathways: SARS-CoV-2 Protein Interactome