TGS1 Protein (AA 713-853, partial) (His-SUMO Tag)
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- Target See all TGS1 Proteins
- TGS1 (Trimethylguanosine Synthase 1 (TGS1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 713-853, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This TGS1 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MRVIAIDIDP VKIALARNNA EVYGIADKIE FICGDFLLLA SFLKADVVFL SPPWGGPDYA TAETFDIRTM MSPDGFEIFR LSKKITNNIV YFLPRNADID QVASLAGPGG QVEIEQNFLN NKLKTITAYF GDLIRRPASE T
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product TGS1 Protein
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Trimethylguanosine Synthase 1 (TGS1) (AA 1-141) protein (GST tag)
TGS1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Trimethylguanosine Synthase 1 (TGS1) (AA 1-853) protein (GST tag)TGS1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Trimethylguanosine Synthase 1 (TGS1) (AA 1-853) protein (Strep Tag)Crystallography grade TGS1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Trimethylguanosine Synthase 1 (TGS1) (AA 1-853) protein (Strep Tag)Crystallography grade TGS1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Trimethylguanosine Synthase 1 (TGS1) (AA 713-853), (partial) protein (His-SUMO Tag)TGS1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- TGS1 (Trimethylguanosine Synthase 1 (TGS1))
- Alternative Name
- TGS1 (TGS1 Products)
- Synonyms
- NCOA6IP Protein, PIMT Protein, PIPMT Protein, D4Ertd800e Protein, Ncoa6ip Protein, Pimt Protein, trimethylguanosine synthase 1 Protein, trimethylguanosine synthase 1 L homeolog Protein, TGS1 Protein, Tgs1 Protein, tgs1.L Protein
- Background
- Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
- Molecular Weight
- 31.64 kDa
- UniProt
- Q96RS0
- Pathways
- Mitotic G1-G1/S Phases, Regulation of Lipid Metabolism by PPARalpha, Ribonucleoprotein Complex Subunit Organization
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