TEAD4 Protein (AA 74-434, partial) (His-SUMO Tag)
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- Target See all TEAD4 Proteins
- TEAD4 (TEA Domain Family Member 4 (TEAD4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 74-434, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This TEAD4 protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MYGRNELIAR YIKLRTGKTR TRKQVSSHIQ VLARRKAREI QAKLKDQAAK DKALQSMAAM SSAQIISATA FHSSMALARG PGRPAVSGFW QGALPGQAGT SHDVKPFSQQ TYAVQPPLPL PGFESPAGPA PSPSAPPAPP WQGRSVASSK LWMLEFSAFL EQQQDPDTYN KHLFVHIGQS SPSYSDPYLE AVDIRQIYDK FPEKKGGLKD LFERGPSNAF FLVKFWADLN TNIEDEGSSF YGVSSQYESP ENMIITCSTK VCSFGKQVVE KVETEYARYE NGHYSYRIHR SPLCEYMINF IHKLKHLPEK YMMNSVLENF TILQVVTNRD TQETLLCIAY VFEVSASEHG AQHHIYRLVK E
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product TEAD4 Protein
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TEA Domain Family Member 4 (TEAD4) (AA 151-260) protein (GST tag)
TEAD4 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
TEA Domain Family Member 4 (TEAD4) (AA 74-434) protein (His tag)TEAD4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
TEA Domain Family Member 4 (TEAD4) (AA 1-361) protein (GST tag)TEAD4 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
TEA Domain Family Member 4 (TEAD4) (AA 1-434) protein (Strep Tag)Crystallography grade TEAD4 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
TEA Domain Family Member 4 (TEAD4) (AA 2-427) protein (His tag)Crystallography grade TEAD4 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
TEA Domain Family Member 4 (TEAD4) (AA 74-434), (partial) protein (His-SUMO Tag)TEAD4 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- TEAD4 (TEA Domain Family Member 4 (TEAD4))
- Alternative Name
- TEAD4 (TEAD4 Products)
- Synonyms
- TEAD4 Protein, rtef1 Protein, tef-3 Protein, eftr-2 Protein, tefr-1 Protein, tcf13l1 Protein, hrtef-1b Protein, xdtef-1 Protein, xlDTEF-1 Protein, RTEF-1 Protein, TEF-1 Protein, TEF-3 Protein, EFTR-2 Protein, RTEF1 Protein, TCF13L1 Protein, TEF3 Protein, TEFR-1 Protein, hRTEF-1B Protein, ETFR-2 Protein, Etfr2 Protein, FR-19 Protein, TEAD-4 Protein, Tcf13r1 Protein, Tef3 Protein, Tefr Protein, Tefr1 Protein, Tefr1a Protein, TEA domain transcription factor 4 Protein, TEA domain transcription factor 4 S homeolog Protein, TEA domain family member 4 Protein, TEAD4 Protein, tead4 Protein, tead4.S Protein, Tead4 Protein
- Background
- Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (T) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
- Molecular Weight
- 56.6 kDa
- UniProt
- Q15561
- Pathways
- Regulation of Lipid Metabolism by PPARalpha
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