SLC12A7 Protein (AA 1-474, full length) (His tag)

Catalog No. ABIN4976968

Product Details

Target: SLC12A7 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7))

Protein Type: Recombinant

Protein Characteristics: full length, AA 1-474

Origin: Rat

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This SLC12A7 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MLKVTVPSCP SSPCSSVTSS TENLVPDYWI DGSKRDPLSD FFEVESELGR GATSIVYRCK QKGTQKPYAL KVLKKTVDKK IVRTEIGVLL RLSHPNIIKL KEIFETPTEI SLVLELVTGG ELFDRIVEKG YYSERDAADA VKQILEAVAY LHENGIVHRD LKPENLLYAT PAPDAPLKIA DFGLSKIVEH QVLMKTVCGT PGYCAPEILR GCAYGPEVDM WSVGIITYIL LCGFEPFYDE RGDQFMFRRI LNCEYYFISP WWDEVSLNAK DLVKKLIVLD PKKRLTTFQA LQHPWVTGKA ANFVHMDTAQ KKLQEFNARR KLKAAVKAVV ASSRLGSASS SHTNIQESNK ASSEAQPAQD GKDKTDPLEN KMQAGDHEAA KAAADETMKL QSEEVEEEEG VKEEEEEEEE EEETSRMVPQ EPEDRLETDD QEMKRNSEET LKSVEEEMDP KAEEEAAAVG LGVPPQQDAI LPEY

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: SLC12A7 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 7 (SLC12A7))

Alternative Name: KCC4 (SLC12A7 Products)

Synonyms: SLC12A7 Protein, KCC4 Protein, Kcc4 Protein, Slc12a5 Protein, AA408796 Protein, D13Ertd261e Protein, solute carrier family 12 (potassium/chloride transporters), member 7 Protein, solute carrier family 12 member 7 Protein, solute carrier family 12, member 7 Protein, SLC12A7 Protein, Slc12a7 Protein

Background: Isoform 1: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and mory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 mory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of tporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to mory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 .Isoform 2: Heat-stable, acidic, calmodulin-binding protein.

Molecular Weight: 57.2 kDa

UniProt: P13234