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Leptin Receptor (LEPR) (AA 1-839) (Active) Protein

Details for Product No. ABIN593496, Supplier: Log in to see
Protein Name
Protein Characteristics
AA 1-839
Origin
Human
17
3
1
Source
Escherichia coli (E. coli)
11
2
2
2
2
1
Protein Type
Recombinant
Biological Activity
Active
Application
High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)
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Specificity Biological Activity is evidenced by high affinity binding of mammalian leptins at 1:1 molar ratio.
Characteristics 95.0 kDa
Biological Activity: Measured by its binding ability in a functional ELISA Immobilized human Leptin at 5 μg/mL (100 μL/well) can bind human Leptin receptor with a linear range of 0.032 - 4.0 μg/mL.
Purity ≥95 %
Background Leptin Binding Domain Human Recombinant also called Leptin soluble receptor produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 208 amino acids and having a molecular mass of 24.5 kDa. Leptin Receptor consists of the cytokine binding domain of leptin receptor amino acids 428-635 of human leptin receptor. The Leptin Binding Domain is purified by proprietary chromatographic techniques.
Synonyms: OB Protein, Obesity Protein, OBS, Obesity factor, recombinant leptin receptor, human leptin, human leptin receptor, recombinant human leptin receptor,
Molecular Weight 95.0 kDa
Gene ID 3952
UniProt P41159
Research Area Cardiovascular, Fatty Acids, Hormones, Receptors
Pathways JAK-STAT Signaling, AMPK Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution The lyophilized Leptin Binding Domain is very soluble in H₂O and most aqueous buffers below and above the isoelectric point (~ 5.9).
Buffer Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Handling Advice Centrifuge the vial prior to opening.
Storage -80 °C
Expiry Date 12 months
Supplier Images
SDS-PAGE (SDS) image for Leptin Receptor (LEPR) (AA 1-839) (Active) Protein (ABIN593496) Leptin Receptor (LEPR) (AA 1-839) (Active) protein
Product cited in: Sato, Schehr, Ikegami: "Leptin does not influence surfactant synthesis in fetal sheep and mice lungs." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 300, Issue 3, pp. L498-505, 2011 (PubMed).