OTUB1 Protein (AA 2-201, partial) (GST tag)
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- Target See all OTUB1 Proteins
- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-201, partial
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This OTUB1 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS), Western Blotting (WB), ELISA
- Sequence
- AAEEPQQQKQ EPLGSDSEGV NCLAYDEAIM AQQDRIQQEI AVQNPLVSER LELSVLYKEY AEDDNIYQQK IKDLHKKYSY IRKTRPDGNC FYRAFGFSHL EALLDDSKEL QRFKAVSAKS KEDLVSQGFT EFTIEDFHNT FMDLIEQVEK QTSVADLLAS FNDQSTSDYL VVYLRLLTSG YLQRESKFFE HFIEGGRTVK
- Purity
- 95 %
- Top Product
- Discover our top product OTUB1 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 6M guanidine hydrochloride, 20mM Tris.
- Storage
- 4 °C
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- Target
- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
- Alternative Name
- Ubiquitin thioesterase OTUB1 (OTUB1 Products)
- Synonyms
- OTB1 Protein, OTU1 Protein, AI850305 Protein, fa19h07 Protein, otub1 Protein, wu:fa19h07 Protein, zgc:92839 Protein, MGC131231 Protein, fb17f04 Protein, otub1l Protein, wu:fb17f04 Protein, zgc:92685 Protein, OTU deubiquitinase, ubiquitin aldehyde binding 1 Protein, OTU domain, ubiquitin aldehyde binding 1 Protein, OTU deubiquitinase, ubiquitin aldehyde binding 1b Protein, OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog Protein, similar to HSPC263 Protein, OTU deubiquitinase, ubiquitin aldehyde binding 1a Protein, OTUB1 Protein, Otub1 Protein, otub1b Protein, otub1.L Protein, otub1 Protein, RGD1565010 Protein, otub1a Protein
- Background
- Background: Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to 'Lys-48'-linked ubiquitin. R. Synonyms: Deubiquitinating enzyme OTUB1 OTU domain-containing ubiquitin aldehyde-binding protein 1 Otubain-1 Short name=hOTU1 Ubiquitin-specific-processing protease OTUB1.
- Molecular Weight
- 50.5 kD
- NCBI Accession
- NM_017670
- UniProt
- Q96FW1
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