Bcl-2 Protein (AA 1-210) (His tag)
-
- Target See all Bcl-2 (BCL2) Proteins
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-210
-
Origin
- Human
- Host
- Please inquire
- Purification tag / Conjugate
- This Bcl-2 protein is labelled with His tag.
- Characteristics
- Recombinant Human B-Cell Leukemia/Lymphoma 2, His6-tagged
- Purity
- > 95.0 % as determined by SDS-PAGE.
- Top Product
- Discover our top product BCL2 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- The protein contains 10mM Tris-HCL pH-8, 1mM EDTA and 250mM NaCl.Suspend BclXL in 100ul of 0.5M Acetic acid, over night at 4°C. Dilute 10 fold into selected buffer system. Bcl-XL has tendency to form intramolecular disulfide bond, 5mM DTT is recommended in assay buffer. When running SDS-PAGE gel, 10mM DTT is recommended.
- Storage
- -20 °C
-
- Target
- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
- Alternative Name
- B-Cell Leukemia/Lymphoma 2 (BCL2 Products)
- Synonyms
- Bcl-2 Protein, PPP1R50 Protein, bcl-2 Protein, AW986256 Protein, C430015F12Rik Protein, D630044D05Rik Protein, D830018M01Rik Protein, BCL-2 Protein, Bcl2 Protein, BCL2, apoptosis regulator Protein, B cell leukemia/lymphoma 2 Protein, B-cell CLL/lymphoma 2a Protein, B-cell CLL/lymphoma 2 protein Protein, BCL2 Protein, Bcl2 Protein, bcl2a Protein, BCL-2 Protein
- Background
- Bcl-XL Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing AA 1-210. The Bcl-XL is expressed as His-Tag fusion protein and purified by proprietary chromatographic techniques. Introduction: Bcl-XL is a transmembrane protein located in the mitochondrial membranes of cells that are long-lived and postmitotic, such as adult brain cells. It plays arole in the signal transduction pathway of the FAS-Ligand. Bcl-XL is an anti-apoptotic protein which is a member of the Bcl-2 family which are able to form heterodimers, and this is an significant event in the regulation of apoptosis. BCL-XL is involved in the survival of cancer cells. Bcl-xL is the leading monitor of apoptosis/active cell suicide. Bcl-xL has cell death repressor activity and therefore acts as a survival protein. Synonyms: BclXL, Bcl-X(L), Bcl-XL.
- Pathways
- MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
-