VHLL Protein (AA 1-154) (His tag)
VHLL
Origin: Human
Recombinant
> 95.0 % as determined by SDS-PAGE.
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- Target See all VHLL Proteins
- VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-154
- Origin
- Human
- Host
- Please inquire
- Purification tag / Conjugate
- This VHLL protein is labelled with His tag.
- Sequence
- MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGPEESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP.
- Characteristics
- Recombinant Human Von Hippel-Lindau Protein
- Purity
- > 95.0 % as determined by SDS-PAGE.
- Top Product
- Discover our top product VHLL Protein
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Von Hippel-Lindau Tumor Suppressor-Like (VHLL) (AA 1-139) protein (Strep Tag)
Crystallography grade VHLL Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- The Von Hippel-Lindau Protein contains 1x PBS pH-7.4, 2mM EDTA, and 1mM DTT.
- Storage
- 4 °C
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- Target
- VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))
- Alternative Name
- Von Hippel-Lindau Protein (VHLL Products)
- Synonyms
- VHLP Protein, VLP Protein, VHL like Protein, VHLL Protein
- Background
- Recombinant Human Von Hippel-Lindau Protein b-domain produced in E. coli is a single, non-glycosylated polypeptide chain containing 174 AA (1-154) and having a molecular mass of 19.2 kDa. The Von Hippel-Lindau antigen is fused to 20 AA His-Tag at N-terminus and purified by proprietary chromatography techniques. Introduction: Von Hippel-Lindau disease is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in b sheet (b-domain) and a smaller a-helical domain (a-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). Synonyms: Von Hippel-Lindau disease tumor suppressor, pVHL, Protein G7, VHL, RCA1, VHL1, HRCA1.
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