MIA Protein

Catalog No. ABIN622772

Product Details

Target: MIA (Melanoma Inhibitory Activity (MIA))

Protein Type: Recombinant

Origin: Human

Host: Please inquire

Sequence: Agrees with the sequence of native human MIA with an addition N-terminal Methionine residue. MGPMPKLADR KLCADQECSS HPISMAVALQ DYMAPDCRFL TIHRGQVVYV FSLKGRGRFL WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKVDVKTDKW DFYCQ

Characteristics: Recombinant Human Melanoma Inhibitory Activity Protein

Purity: > 95.0 % as determined by: 1) Analysis by RP-HPLC. 2) Analysis by SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: The protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Potassium-phosphate pH 7.0 and 150mM potassium chloride.It is recommended to reconstitute the lyophilized Melanoma Inhibitory Activity in sterile 18MO-cm H 2 O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage: -20 °C

Target Details

Target: MIA (Melanoma Inhibitory Activity (MIA))

Alternative Name: Melanoma Inhibitory Activity Protein (MIA Products)

Synonyms: CD-RAP Protein, Mia1 Protein, Cdrap Protein, zgc:194157 Protein, mia Protein, CDRAP Protein, Fdp Protein, MIA Protein, MIAL Protein, melanoma inhibitory activity Protein, otoraplin Protein, cilia and flagella associated protein 100 Protein, MIA Protein, Mia Protein, mia Protein, Otor Protein, CFAP100 Protein

Background: Melanoma Inhibitory Activity Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 108 amino having a total molecular mass of 12237 Dalton. The MIA is purified by proprietary chromatographic techniques. Introduction: The Melanoma Inhibitory protein (MIA) was identified as an inhibitor of in vitro growth of malignant melanoma cells. The protein contains a SH3 domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion. In a study of human melanoma cell lines with different metastatic capacity MIA mRNA expression appeared to be inversely correlated with pigmentation. MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas. Synonyms: Melanoma-derived growth regulatory protein precursor, Cartilage-derived retinoic acid-sensitive protein, CD-RAP, MIA.