AMBP Protein

Catalog No. ABIN621846

Product Details

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Origin: Human

Source: Human

Characteristics: Human Urinary Trypsin Inhibitor

Purity: > 98.0 % as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from a (1mg/ml) solution containing no additives.It is recommended to reconstitute the lyophilized UTI in sterile 18M omega cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Storage: -20 °C

Target Details

Target: AMBP (alpha 1 Microglobulin/bikunin precursor (AMBP))

Alternative Name: Urinary Trypsin Inhibitor (AMBP Products)

Synonyms: A1M Protein, EDC1 Protein, HI30 Protein, IATIL Protein, ITI Protein, ITIL Protein, ITILC Protein, UTI Protein, ambp Protein, MGC64242 Protein, AMBP Protein, DKFZp470D2211 Protein, AI194774 Protein, ASPI Protein, HI-30 Protein, Intin4 Protein, Itil Protein, ambpl Protein, zgc:66321 Protein, alpha-1-microglobulin/bikunin precursor Protein, alpha-1-microglobulin/bikunin precursor L homeolog Protein, alpha 1 microglobulin/bikunin Protein, AMBP Protein, Ambp Protein, ambp.L Protein, ambp Protein

Background: Ulinastatin is derived from human urine. Introduction: Urinary-Trypsin Inhibitor is a glucoprotein proteinase inhibitor with a molecular weight of about 67,000 derived from human urine which inhibits the activity of trypsin, chymotrypsin, lactate, lipase, hyaluronidase and various pancreatic enzymes. Ulinastatin is effective for acute pancreatitis, chronic recurrent pancreatitis and hemorrhagic, traumatic and endotoxic shocks. Ulinastatin is has strong inhibition effect to various protease, sugar and fat hydrolase. Ulinastatin precursor is proteolytically processed into distinct functioning proteins. Urinary trypsin inhibitor belongs to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. Uristatin gene is located on chromosome 9 in a cluster of lipocalin genes. High levels of Ulinastatin secretion is an early marker of renal tubular involvement and has radical scavenging activity. Bikunin localizes cell membrane. Free uristatin and bikunin pass readily into urine and are primarily bound to heavy chains that constitute the proinhibitor form in plasma. Ulinastatin particularly interacts with ORF3 protein of hepatitis E virus and in charge for enhancing alpha microglobulin export from the hepatocyte. Synonyms: UTI, Bikunin, Uristatin, Ulinastatin, AMBP, EDC1, HI30, ITIL, IATIL, ITILC, Urinary Trypsin Inhibitor.