Glutathione Synthetase Protein (GSS) (AA 1-474) (His tag)

Catalog No. ABIN666628

Product Details

Target: Glutathione Synthetase (GSS)

Protein Type: Recombinant

Protein Characteristics: AA 1-474

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Glutathione Synthetase protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: GSS, 1-474aa, Human, His tag, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Storage: 4 °C

Target Details

Target: Glutathione Synthetase (GSS)

Alternative Name: GSS (GSS Products)

Synonyms: PRNP Protein, 6835 Protein, CG32497 Protein, CG33065 Protein, CG6835 Protein, Dmel\\CG6835 Protein, F21A20.90 Protein, F21A20_90 Protein, GLUTATHIONE SYNTHETASE Protein, GSHB Protein, glutathione synthetase 2 Protein, GSHS Protein, AI314904 Protein, GS-A/GS-B Protein, gssls-a Protein, glutathione synthetase Protein, Glutathione Synthetase Protein, glutathione synthetase 2 Protein, glutathione synthetase L homeolog Protein, GSS Protein, GSH2 Protein, Tola_1250 Protein, PC1_3711 Protein, Dd586_3633 Protein, Kvar_0701 Protein, Alvin_0197 Protein, Nhal_0215 Protein, BC1002_0254 Protein, Cseg_4017 Protein, Snov_3844 Protein, Aazo_1904 Protein, M301_2613 Protein, Bresu_0515 Protein, Isop_1460 Protein, Marme_4020 Protein, Thicy_0325 Protein, Sinme_3668 Protein, Mesop_0757 Protein, Gss Protein, gss.L Protein

Background: Glutathione synthetase, also known GSS, is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione. Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency), also known as 5-oxoprolinuria or pyroglutamic aciduria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. Recombinant human GSS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Glutathione synthetase, GSHS, GSH synthetase. NCBI no.: NP_000169

Molecular Weight: 54.5 kDa (494aa) confirmed by MALDI-TOF

Pathways: Warburg Effect