14-3-3 sigma/SFN Protein (AA 1-248)
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- Target See all 14-3-3 sigma/SFN (SFN) Proteins
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-248
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Characteristics
- 14-3-3 sigma, 1-248aa, Human, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product SFN Protein
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Stratifin (SFN) (AA 1-248) protein (GST tag)
SFN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Stratifin (SFN) (AA 3-238) protein (GST tag)SFN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Stratifin (SFN) (AA 1-248) protein (Strep Tag)Crystallography grade SFN Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Stratifin (SFN) (AA 1-248), (full length) protein (GST tag)SFN Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
Stratifin (SFN) proteinSFN Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % WB, SDS, ELISA, IP
Stratifin (SFN) protein (Myc-DYKDDDDK Tag)SFN Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol
- Storage
- 4 °C
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- Target
- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
- Alternative Name
- 14-3-3 sigma (SFN Products)
- Synonyms
- YWHAS Protein, Er Protein, Mme1 Protein, Ywhas Protein, stratifin Protein, SFN Protein, Sfn Protein
- Background
- 14-3-3 sigma ,also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: stratifin, Epithelial cell marker protein 1, HME1, YWHAS, SFN, 14-3-3 sigma. NCBI no.: NP_006133
- Molecular Weight
- 27.7 kDa (248aa), confirmed by MALDI-TOF.
- Pathways
- p53 Signaling, Myometrial Relaxation and Contraction
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