TYMS Protein (AA 1-313) (His tag)
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- Target See all TYMS Proteins
- TYMS (Thymidylate Synthetase (TYMS))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-313
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This TYMS protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- Thymidylate synthase, 1-313aa, Human, His tag, E.coli
- Purity
- > 95 % by SDS - PAGE
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Thymidylate Synthetase (TYMS) (AA 1-313) protein (GST tag)
TYMS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Thymidylate Synthetase (TYMS) (AA 111-210) protein (GST tag)TYMS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Thymidylate Synthetase (TYMS) (AA 2-313) protein (His tag)Crystallography grade TYMS Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Thymidylate Synthetase (TYMS) protein (Myc-DYKDDDDK Tag)TYMS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.
- Storage
- 4 °C
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- Target
- TYMS (Thymidylate Synthetase (TYMS))
- Alternative Name
- Thymidylate synthase (TYMS Products)
- Synonyms
- FN1 Protein, ECK2823 Protein, JW2795 Protein, ts Protein, Ts Protein, HST422 Protein, TMS Protein, TS Protein, thymidylate synthetase Protein, contains intron in T4 phage Protein, ThyE Protein, thymidylate synthase Protein, thymidylate synthetase L homeolog Protein, TYMS Protein, thyA Protein, td Protein, thyE Protein, DDA3937_RS04960 Protein, tyms.L Protein, XBJ1_RS15770 Protein, EAMY_RS20680 Protein, Tyms Protein
- Target Type
- Viral Protein
- Background
- Thymidylate synthase is an intracellular enzyme critical for de novo synthesis of DNA. This function maintains the dTMP(thymidine-5-prime monophosphate) pool critical for DNA replication and repair. In cancer, expression of this protein is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of thymidylate synthase activity. Recombinant human Thymidylate synthase protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: HST422, TMS, TS, d TMP synthase, EC 2.1.1.45, MGC88736, Thymidylate synthase, Thymidylate synthetase, Tsase, TYMS, TYMS protein, Tyms thymidylate synthetase,. NCBI no.: NP_001062
- Molecular Weight
- 37.8 kDa (333aa), confirmed by MALDI-TOF.
- Pathways
- Mitotic G1-G1/S Phases
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