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SQSTM1 Protein (AA 1-356) (His tag)

SQSTM1 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS-PAGE SDS
Catalog No. ABIN666979
  • Target See all SQSTM1 Proteins
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-356
    Origin
    • 7
    • 2
    • 2
    • 1
    Human
    Source
    • 6
    • 2
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This SQSTM1 protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Characteristics
    SQSTM1, 1-356 aa, Human, His-tagged, Recombinant, E.coli
    Purity
    > 90 % by SDS-PAGE
    Top Product
    Discover our top product SQSTM1 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/ml (determined by Bradford assay)
    Buffer
    Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
    Storage
    4 °C
  • Target
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Alternative Name
    SQSTM1 (SQSTM1 Products)
    Synonyms
    SQSTM1 Protein, sqstm1 Protein, MGC79491 Protein, A170 Protein, OSIL Protein, PDB3 Protein, ZIP3 Protein, p60 Protein, p62 Protein, p62B Protein, OSF-6 Protein, Osi Protein, STAP Protein, ZIP Protein, sb:cb621 Protein, zgc:85784 Protein, sequestosome 1 Protein, sequestosome 1 L homeolog Protein, SQSTM1 Protein, sqstm1 Protein, Sqstm1 Protein, sqstm1.L Protein
    Background
    SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 protein commonly cause Paget’s disease since the UBA is necessary for aggregate sequestration and cell survival. Recombinant SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: A170, OSIL, p60, p62, p62B, PDB3, ZIP3, Sequestosome 1 EBI 3 associated protein of 60 kDa, ZIP, ZIP 3, EBI3 associated protein of 60 kDa, EBIAP, MGC127197, ORCA.M530, OSF-6, Osi, Oxidative stress induced like, Paget disease of bone 3, PDB 3, Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa, Phosphotyrosine independent ligand for the Lck SH2 domain p62, PKC-zeta-interacting protein, Protein kinase C-zeta-interacting protein, SQSTM 1, STAP, STONE14, Ubiquitin binding protein p62,. NCBI no.: NP_001135771
    Molecular Weight
    39.7 kDa (364aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
    Pathways
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
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