SQSTM1 Protein (AA 1-356) (His tag)
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- Target See all SQSTM1 Proteins
- SQSTM1 (Sequestosome 1 (SQSTM1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-356
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This SQSTM1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- SQSTM1, 1-356 aa, Human, His-tagged, Recombinant, E.coli
- Purity
- > 90 % by SDS-PAGE
- Top Product
- Discover our top product SQSTM1 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
- Storage
- 4 °C
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- Target
- SQSTM1 (Sequestosome 1 (SQSTM1))
- Alternative Name
- SQSTM1 (SQSTM1 Products)
- Synonyms
- SQSTM1 Protein, sqstm1 Protein, MGC79491 Protein, A170 Protein, OSIL Protein, PDB3 Protein, ZIP3 Protein, p60 Protein, p62 Protein, p62B Protein, OSF-6 Protein, Osi Protein, STAP Protein, ZIP Protein, sb:cb621 Protein, zgc:85784 Protein, sequestosome 1 Protein, sequestosome 1 L homeolog Protein, SQSTM1 Protein, sqstm1 Protein, Sqstm1 Protein, sqstm1.L Protein
- Background
- SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 protein commonly cause Paget’s disease since the UBA is necessary for aggregate sequestration and cell survival. Recombinant SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: A170, OSIL, p60, p62, p62B, PDB3, ZIP3, Sequestosome 1 EBI 3 associated protein of 60 kDa, ZIP, ZIP 3, EBI3 associated protein of 60 kDa, EBIAP, MGC127197, ORCA.M530, OSF-6, Osi, Oxidative stress induced like, Paget disease of bone 3, PDB 3, Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa, Phosphotyrosine independent ligand for the Lck SH2 domain p62, PKC-zeta-interacting protein, Protein kinase C-zeta-interacting protein, SQSTM 1, STAP, STONE14, Ubiquitin binding protein p62,. NCBI no.: NP_001135771
- Molecular Weight
- 39.7 kDa (364aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
- Pathways
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
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