Retinoic Acid Receptor alpha Protein (AA 68-173) (His tag)

Catalog No. ABIN667055

Product Details

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Protein Type: Recombinant

Protein Characteristics: AA 68-173

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Retinoic Acid Receptor alpha protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: RARalpha, 68-173aa, Human, His-tagged, Recombinant, E.coli

Purity: > 95 % by SDS-PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid in 20mM Tris pH 7.5, 0.1M NaCl, 5mM beta-mercaptoethanol

Storage: 4 °C

Target Details

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Alternative Name: RARalpha (RARA Products)

Synonyms: NR1B1 Protein, RAR Protein, Nr1b1 Protein, RARalpha1 Protein, rar-alpha Protein, etID309833.12 Protein, rara Protein, rara2a Protein, zRAR Protein, zRAR-alpha Protein, zgc:109797 Protein, nr1b1 Protein, RAR-ALPHA1 Protein, HS-RARa Protein, fj66e06 Protein, rara2b Protein, wu:fj66e06 Protein, retinoic acid receptor alpha Protein, retinoic acid receptor, alpha Protein, retinoic acid receptor, alpha a Protein, retinoic acid receptor alpha L homeolog Protein, retinoic acid receptor, alpha b Protein, RARA Protein, Rara Protein, LOC100136372 Protein, raraa Protein, rara.L Protein, rara Protein, rarab Protein

Background: Retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. Three isotypes of RARs, alpha, beta, and gamma, are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically, RAR-alpha represses target gene transcription in the absence of hormone, whereas RAR-beta and gamma fail to repress under these conditions. Recombinant human RARalpha, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: NR1B1, Retinoic acid receptor alpha, Retinoic acid receptor, alpha isoform 1, RAR alpha, RARalpha, RAR , Retinoic acid receptor, alpha isoform 1. NCBI no.: NP_000955

Molecular Weight: 14 kDa (127 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins