HIF1A Protein (AA 576-785) (His tag)
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- Target See all HIF1A Proteins
- HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 576-785
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This HIF1A protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- HIF1A, 576-785aa, Human, His tag, E.coli
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product HIF1A Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 1mM DTT, 10% glycerol
- Storage
- 4 °C
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- Target
- HIF1A (Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A))
- Alternative Name
- HIF1A (HIF1A Products)
- Synonyms
- hif1a Protein, AA959795 Protein, HIF1alpha Protein, MOP1 Protein, bHLHe78 Protein, HIF-1A Protein, HIF-1alpha Protein, HIF1 Protein, HIF1-ALPHA Protein, PASD8 Protein, HIF1-alpha Protein, hif-1a Protein, hypoxia inducible factor 1 alpha Protein, hypoxia inducible factor 1, alpha subunit Protein, hypoxia inducible factor 1 alpha subunit Protein, HIF (Hypoxia Inducible Factor) homologa Protein, hif-1a Protein, Hif1a Protein, HIF1A Protein, hif1a Protein, hif-1 Protein
- Background
- HIF1A, identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. This protein is a heterodimer composed of HIF-1beta subunit and one of three subunits(HIF-1A, HIF-2A or HIF-3A). The activation of HIF1A is closely associated with a variety of tumors and oncogenic pathways. HIF1A consists of DNA binding domain(DBD domain), Dimerization domain and C-terminla regulatiory domains, including two transactivation domains(TAD), an oxygen-dependent degradation(ODD) domain, and inhibitory domains. Recombinant human HIF1A(576-785) protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: BHLHE78, MOP1, PASD8, Hypoxia-inducible factor 1-alpha. NCBI no.: NP_001521
- Molecular Weight
- 25.1 kDa (231aa) confirmed by MALDI-TOF (Real molecular weight on SDS-PAGE will be shift up)
- Pathways
- Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals, Warburg Effect
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