PNP Protein (AA 1-289) (His tag)
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- Target See all PNP (NP) Proteins
- PNP (NP) (Nucleoside Phosphorylase (NP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-289
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PNP protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- PNP, 1-289aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product NP Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.1M NaCl, 2mM DTT, 10% glycerol
- Storage
- 4 °C
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- Target
- PNP (NP) (Nucleoside Phosphorylase (NP))
- Alternative Name
- PNP (NP Products)
- Synonyms
- NP Protein, PRO1837 Protein, PUNP Protein, Np Protein, AL024301 Protein, AU015798 Protein, Np-1 Protein, Np-2 Protein, Pnp1 Protein, purine nucleoside phosphorylase Protein, purine-nucleoside phosphorylase Protein, PNP Protein, Pnp Protein
- Target Type
- Viral Protein
- Background
- PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2’-deoxyribonucleosides with specificity for guanine, hypoxanthine and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases. Recombinant human PNP protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Purine nucleoside phosphorylase, NP, Inosine phosphorylase, PRO1837, PUNP. NCBI no.: NP_000261
- Molecular Weight
- 34.2 kDa (309aa) confirmed by MALDI-TOF
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Ribonucleoside Biosynthetic Process, Positive Regulation of Response to DNA Damage Stimulus
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