B-Cell Linker Protein (BLNK) (AA 1-456) (His tag)
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- Target See all B-Cell Linker (BLNK) Proteins
- B-Cell Linker (BLNK)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-456
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This B-Cell Linker protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- BLNK, 1-456aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product BLNK Protein
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B-Cell Linker (BLNK) (AA 1-456) protein (GST tag)
BLNK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
B-Cell Linker (BLNK) (AA 301-400) protein (GST tag)BLNK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
B-Cell Linker (BLNK) (AA 1-456) protein (His tag)BLNK Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
B-Cell Linker (BLNK) (AA 1-456) protein (Strep Tag)Crystallography grade BLNK Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
B-Cell Linker (BLNK) (AA 1-457) protein (Strep Tag)Crystallography grade BLNK Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.0 mg/ml (determined by BCA assay)
- Buffer
- Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF
- Storage
- 4 °C
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- Target
- B-Cell Linker (BLNK)
- Alternative Name
- BLNK (BLNK Products)
- Synonyms
- BLNK Protein, blnk Protein, MGC147045 Protein, BASH Protein, Bca Protein, Ly-57 Protein, Ly57 Protein, Lyw-57 Protein, SLP-65 Protein, AGM4 Protein, BLNK-S Protein, LY57 Protein, SLP65 Protein, bca Protein, B-cell linker Protein, B cell linker Protein, BLNK Protein, blnk Protein, Blnk Protein
- Background
- BLNK, also known as B-cell linker, is essential for normal B-cell development. This protein has been shown to associate with the effector proteins GRB2, Vav, NCK and PLC gamma following activation of the B cell receptor. It is phosphorylated by the Syk tyrosine kinase, which in turn permits activation of downstream effector proteins including GRB2 and PLC gamma. Recombinant human BLNK protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: B-cell linker, BASH, BLNK-S, LY57, MGC111051, SLP-65, SLP65. NCBI no.: AAH18906
- Molecular Weight
- 52.6 kDa (476aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
- Pathways
- BCR Signaling
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