C-JUN Protein (AA 1-241) (His tag)

Catalog No. ABIN667382

Product Details

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Protein Type: Recombinant

Protein Characteristics: AA 1-241

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This C-JUN protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: c-Jun, 1-241aa, Human, His tag, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 2mM DTT, 0.1M NaCl.

Storage: 4 °C

Target Details

Target: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Alternative Name: c-Jun (JUN Products)

Synonyms: AP-1 Protein, AP1 Protein, c-Jun Protein, fj36h07 Protein, wu:fj36h07 Protein, zgc:65863 Protein, Junc Protein, c-jun Protein, CG2275 Protein, D-Jun Protein, D-jun Protein, D-jun/Jra Protein, DJUN Protein, DJun Protein, Djun Protein, Dmel\\CG2275 Protein, JRA Protein, JUN Protein, Jun Protein, V Protein, cJun Protein, d-JRA Protein, d-Jun Protein, d-jun Protein, dAP-1 Protein, dJRA Protein, dJUN Protein, dJra Protein, dJun Protein, djun Protein, dm-Jun Protein, jra Protein, jun Protein, l(2)46Ef Protein, l(2)IA109 Protein, l(2R)IA109 Protein, Jun proto-oncogene, AP-1 transcription factor subunit Protein, jun proto-oncogene S homeolog Protein, jun proto-oncogene Protein, Jun-related antigen Protein, jun proto-oncogene L homeolog Protein, JUN Protein, Jun Protein, jun.S Protein, jun Protein, Jra Protein, jun.L Protein

Background: The human protooncogene c-Jun is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. c-Jun and c-Fos form a complex in the nucleus. AP1 is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21, p19 and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. Recombinant human c-Jun protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Transcription factor AP-1, AP-1, AP1, c-Jun, jun proto-oncogene. NCBI no.: NP_002219

Molecular Weight: 27.3 kDa (261 aa) confirmed by MALDI-TOF

Pathways: MAPK Signaling, RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins