PPME1 Protein (AA 1-386) (His tag)
-
- Target See all PPME1 Proteins
- PPME1 (Protein Phosphatase Methylesterase 1 (PPME1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-386
-
Origin
- Human
-
Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This PPME1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- PPME1, 1-386aa, Human, His tag, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product PPME1 Protein
-
-
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT
- Storage
- 4 °C
-
- Target
- PPME1 (Protein Phosphatase Methylesterase 1 (PPME1))
- Alternative Name
- PPME1 (PPME1 Products)
- Synonyms
- PME-1 Protein, 1110069N17Rik Protein, 2700017M01Rik Protein, Pme1 Protein, fk72d03 Protein, zgc:56239 Protein, wu:fk72d03 Protein, RGD1309683 Protein, PME1MGC133824 Protein, F28M11.4 Protein, DDBDRAFT_0204584 Protein, DDBDRAFT_0305014 Protein, DDB_0204584 Protein, DDB_0305014 Protein, PME1 Protein, CaO19.1459 Protein, protein phosphatase methylesterase 1 Protein, protein phosphatase methylesterase 1 S homeolog Protein, esterase/lipase/thioesterase family protein Protein, carboxylesterase-mitochondrial 37S ribosomal protein YmS2 Protein, PPME1 Protein, Ppme1 Protein, ppme1 Protein, ppme1.S Protein, AT4G10050 Protein, PPE1 Protein
- Background
- PPME1, also known protein phosphatase methylesterase-1(PME1), catalyzes the demethylation and inactivation of protein phosphatase (PP2A), which is a multimeric phosphoserine/ threonine protein phosphatase associated with growth inhibition and cell cycle arrest. It can demethylate PP2A catalytic subunit in vitro and okadaic acid treatment is capable of inhibiting this reaction. It is conserved from yeast to human and contains a motif found in lipases having a catalytic triad activated serine as their active site nucleophile. Recombinant human PPME1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Protein phosphatase methylesterase 1, FLJ22226, PME-1. NCBI no.: NP_057231
- Molecular Weight
- 44.4 kDa(406aa), confirmed by MALDI-TOF
- Pathways
- Methionine Biosynthetic Process
-