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RAB32 Protein (AA 1-225) (His tag)

RAB32 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Catalog No. ABIN667585
  • Target See all RAB32 Proteins
    RAB32 (RAB32, Member RAS Oncogene Family (RAB32))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 1-225
    Origin
    • 5
    • 1
    Human
    Source
    • 3
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This RAB32 protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Characteristics
    RAB32, 1-225aa, Human, His tag, E.coli
    Purity
    > 90 % by SDS - PAGE
    Top Product
    Discover our top product RAB32 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5mg/ml (determined by Bradford assay)
    Buffer
    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 50% glycerol, 200mM NaCl, 2mM EDTA
    Storage
    4 °C
  • Target
    RAB32 (RAB32, Member RAS Oncogene Family (RAB32))
    Alternative Name
    RAB32 (RAB32 Products)
    Synonyms
    cb914 Protein, hm:zehn1770 Protein, rab32 Protein, zgc:110481 Protein, MGC130912 Protein, RAB32 Protein, LOC100224194 Protein, 2810011A17Rik Protein, AU022057 Protein, RGD1559997 Protein, RAB32a, member RAS oncogene family Protein, RAB32, member RAS oncogene family Protein, RAB32, member RAS oncogene family S homeolog Protein, rab32a Protein, rab32 Protein, RAB32 Protein, rab32.S Protein, Rab32 Protein
    Background
    RAB32 belongs to the small GTPase superfamily. RAB32 modulates ER calcium handling and disrupts the specific enrichment of calnexin on the MAM (mitochondria-associated membrane), while not affecting the ER distribution of protein-disulfide isomerase and mitofusin-2. Also, RAB32 determines the targeting of PKA (cAMP-dependent protein kinase) to mitochondrial and ER membranes and through its overexpression or inactivation increases the phosphorylation of Bad and of Drp1. Through a combination of its functions as a PKA-anchoring protein and a regulator of MAM properties, the activity and expression level of RAB32 determine the speed of apoptosis onset. Recombinant human RAB32 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Ras-related protein Rab-32,. NCBI no.: NP_006825
    Molecular Weight
    27.6kDa (249aa), confirmed by MALDI-TOF
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