HMBS Protein (AA 1-361) (His tag)
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- Target See all HMBS Proteins
- HMBS (Hydroxymethylbilane Synthase (HMBS))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-361
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This HMBS protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- HMBS, 1-361aa , Human, His tag, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product HMBS Protein
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Hydroxymethylbilane Synthase (HMBS) (AA 1-361) protein (His tag)
HMBS Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Hydroxymethylbilane Synthase (HMBS) (AA 1-361) protein (GST tag)HMBS Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Hydroxymethylbilane Synthase (HMBS) (AA 2-361) protein (His tag)Crystallography grade HMBS Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Hydroxymethylbilane Synthase (HMBS) (AA 2-361) protein (His tag)Crystallography grade HMBS Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Hydroxymethylbilane Synthase (HMBS) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)HMBS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Hydroxymethylbilane Synthase (HMBS) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)HMBS Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl
- Storage
- 4 °C
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- Target
- HMBS (Hydroxymethylbilane Synthase (HMBS))
- Alternative Name
- HMBS (HMBS Products)
- Synonyms
- PBG-D Protein, PBGD Protein, PORC Protein, UPS Protein, URO-S Protein, hemC Protein, pbg-d Protein, pbgd Protein, ups Protein, SPAC806.01 Protein, DDBDRAFT_0186148 Protein, DDBDRAFT_0231417 Protein, DDB_0186148 Protein, DDB_0231417 Protein, Hmbs Protein, NV50236 Protein, T25658 Protein, Ups Protein, Uros1 Protein, hmbs Protein, zgc:64128 Protein, hmbsl Protein, id:ibd5004 Protein, im:7140060 Protein, zgc:110690 Protein, hydroxymethylbilane synthase Protein, hydroxymethylbilane synthase S homeolog Protein, hydroxymethylbilane synthase L homeolog Protein, hydroxymethylbilane synthase (predicted) Protein, Hydroxymethylbilane synthase Protein, hydroxymethylbilane synthase a Protein, hydroxymethylbilane synthase, b Protein, HMBS Protein, Hmbs Protein, hmbs Protein, hmbs.2.S Protein, hmbs.L Protein, CNC02250 Protein, hem3 Protein, hemC Protein, Trad_0335 Protein, Plabr_2100 Protein, Sgly_3113 Protein, SMLT_RS19660 Protein, PMI_RS16580 Protein, hmbsa Protein, hmbsb Protein
- Background
- Porphobilinogen deaminase, also known as HMBS, is a member of the hydroxymethylbilane synthase superfamily. It is a cytoplasmic enzyme found in the heme synthesis pathway. Deficiency of HMBS causes errors in pyrrole metabolism which in turn leads to an inherited autosomal disorder called acute intermittent porphyria (AIP) which is characterized by acute attacks of neurological dysfunctions with hypertension, tachycardia, peripheral neurologic disturbances, abdominal pain and excessive amounts of aminolevulinic acid and porphobilinogen in the urine. Recombinant human HMBS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: PBG-D, PBGD, PORC, UPS. NCBI no.: NP_000181
- Molecular Weight
- 41.9kDa (385aa) confirmed by MALDI-TOF
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