DECR1 Protein (AA 35-335) (His tag)
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- Target See all DECR1 Proteins
- DECR1 (2,4-Dienoyl CoA Reductase 1, Mitochondrial (DECR1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 35-335
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DECR1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- DECR1, 35-335aa, Human, His tag, E.coli
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product DECR1 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT.
- Storage
- 4 °C
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- Target
- DECR1 (2,4-Dienoyl CoA Reductase 1, Mitochondrial (DECR1))
- Alternative Name
- DECR1 (DECR1 Products)
- Synonyms
- DECR Protein, NADPH Protein, SDR18C1 Protein, 1200012F07Rik Protein, Decr Protein, Nadph Protein, fe38b07 Protein, wu:fe38b07 Protein, zgc:92356 Protein, 2,4-dienoyl-CoA reductase 1 Protein, 2,4-dienoyl CoA reductase 1, mitochondrial Protein, 2,4-dienoyl-CoA reductase 1 L homeolog Protein, DECR1 Protein, Decr1 Protein, decr1 Protein, decr1.L Protein
- Background
- DECR1 is a mitochondrial protein that exists as a homotetramer and belongs to the family of short-chain dehydrogenases/reductases. It functions as an auxiliary enzyme of beta-oxidation andt participates in the metabolism of unsaturated fatty enoyl-CoA esters. Specifically, DECR1 uses NADP+ to catalyze the reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA, which can then be used as an intermediate in the Krebs cycle. Additionally, DECR1 is thought to function as a tumor suppressor, possibly downregulating the expression of Neu and slowing the rate of tumorigenesis. Recombinant human DECR1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: 2,4-dienoyl-CoA reductase, mitochondrial, DECR, NADPH, SDR18C1. NCBI no.: NP_001350
- Molecular Weight
- 34.4 kDa (322aa), confirmed by MALDI-TOF
- Pathways
- Monocarboxylic Acid Catabolic Process
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