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POMC Protein (AA 27-267) (His tag)

POMC Origin: Human Host: Escherichia coli (E. coli) Recombinant > 85 % by SDS - PAGE SDS
Catalog No. ABIN667920
  • Target See all POMC Proteins
    POMC (Proopiomelanocortin (POMC))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 27-267
    Origin
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 11
    • 6
    • 2
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This POMC protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Characteristics
    POMC, 27-267aa, Human, His tag, E.coli
    Purity
    > 85 % by SDS - PAGE
    Top Product
    Discover our top product POMC Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/ml (determined by Bradford assay)
    Buffer
    Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.2M NaCl
    Storage
    4 °C
  • Target
    POMC (Proopiomelanocortin (POMC))
    Alternative Name
    POMC (POMC Products)
    Synonyms
    MSH Protein, ACTH Protein, pomc Protein, SI:bZ36D5.1 Protein, SI:bZ36D5.4 Protein, si:bz36d5.2 Protein, BE Protein, Beta-LPH Protein, Clip Protein, Gamma-LPH Protein, Npp Protein, Pomc-1 Protein, Pomc1 Protein, alpha-MSH Protein, alphaMSH Protein, beta-MSH Protein, gamma-MSH Protein, CLIP Protein, LPH Protein, NPP Protein, POC Protein, Pomc2 Protein, proopiomelanocortin a Protein, pro-opiomelanocortin-alpha Protein, proopiomelanocortin Protein, pomca Protein, Pomc Protein, POMC Protein
    Background
    Pro-opiomelanocortin preproprotein, also known as POMC, a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. It regulates the corticosteroid production in the adrenal cortex. Also, POMC is cleaved into ten hormone chains named NPP, gamma-MSH, ACTH, alpha-MSH, CLIP, Lipotropin beta, Lipotropin gamma, beta-MSH, beta endorphin and Met-enkephalin. Defects in the gene that encodes POMC are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency. Recombinant human POMC protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Pro-opiomelanocortin preproprotein, ACTH, CLIP, LPH, MSH, NPP, POC. NCBI no.: NP_001030333
    Molecular Weight
    28.9 kDa (262aa), confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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