NFKBIA Protein (AA 1-317) (His tag)

Catalog No. ABIN667968

Product Details

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Protein Type: Recombinant

Protein Characteristics: AA 1-317

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This NFKBIA protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: NFKBIA, 1-317aa, Human, His tag, E.coli

Purity: > 90 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.1M NaCl

Storage: 4 °C

Target Details

Target: NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))

Alternative Name: NFKBIA (NFKBIA Products)

Synonyms: IKBA Protein, MAD-3 Protein, NFKBI Protein, AI462015 Protein, Nfkbi Protein, RL/IF-1 Protein, ECI-6/IKBA Protein, NFKBIA Protein, ikbaB Protein, wu:fb81f08 Protein, zgc:56666 Protein, zgc:77616 Protein, ikbaA Protein, wu:fj16a07 Protein, zgc:85769 Protein, NFKB inhibitor alpha Protein, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a Protein, NFKBIA Protein, Nfkbia Protein, nfkbiab Protein, nfkbiaa Protein

Background: NF-kappa-B inhibitor alpha, also known as NFKBIA, is members of the IkB family of proteins can be divided into four groups (IkB-alpha, IkB-beta, IkB-gamma, IkB-epsilon). NFKBIA inhibits the NFkB complex by binding and sequestering it in the cytoplasm. Upon stimulation, NFKBIA is phosphorylated on serine residues marking it for degradation by the ubiquitin pathway. Recombinant human NFKBIA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: NF-kappa-B inhibitor alpha, IKBA, MAD-3, NFKBI. NCBI no.: NP_065390

Molecular Weight: 37.7 kDa (337aa), confirmed by MALDI-TOF

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling