Succinate Dehydrogenase Complex Assembly Factor 2 (Sdhaf2) (AA 30-166) protein (His tag)

Details for Product No. ABIN807306, Supplier: Log in to see
Protein Name
  • C14H11orf79
  • C11orf79
  • PGL2
  • SDH5
  • 0610038F07Rik
  • AA407634
  • AW049997
  • RGD1309216
  • wu:fj30e04
  • zgc:163000
  • succinate dehydrogenase complex assembly factor 2
  • SDHAF2
  • LOC100353725
  • Sdhaf2
  • sdhaf2
Protein Characteristics
AA 30-166
2
2
1
Origin
Human
4
1
1
1
1
Source
Escherichia coli (E. coli)
4
3
1
Protein Type
Recombinant
Purification tag / Conjugate
This Sdhaf2 protein is labelled with His tag.
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Sequence MGSSHHHHHH SSGLVPRGSH MGSSFRRFYR GDSPTDSQKD MIEIPLPPWQ ERTDESIETK RARLLYESRK RGMLENCILL SLFAKEHLQH MTEKQLNLYD RLINEPSNDW DIYYWATEAK PAPEIFENEV MALLRDFAKN KNKEQRLRAP DLEYLFEKPR.
Characteristics SDHAF2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 AA (30-166 AA) and having a molecular mass of 19kDa. SDHAF2 is fused to a 23 AA His-tag at N-terminus & purified by proprietary chromatographic techniques.
Purity > 90 % as determined by (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE
Sterility Sterile filtered
Background Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2) is a mitochondrial protein required for the flavination of a succinate dehydrogenase complex subunit essential for activity of the complex. DHAF2 is necessary for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDHAF2 gene defects are the cause of hereditary paragangliomas type 2 (PGL2), otherwise known as familial non-chromaffin paragangliomas type 2.
Molecular Weight 50.2 kDa
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer 25 mM Tris-HCl buffer (pH 8.0), 0.2 M NaCl, 30 % glycerol and 5 mM DTT.
Handling Advice Please avoid freeze thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C if entire vial will be used within 2-4 weeks. Store, frozen at -20 °C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
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