RCAN1 Protein (AA 1-117, Isoform B)
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- Target See all RCAN1 Proteins
- RCAN1 (Regulator of Calcineurin 1 (RCAN1))
- Protein Type
- Recombinant
- Protein Characteristics
- Isoform B, AA 1-117
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS)
- Sequence
- MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMRRPK PKIIQTRRPE YTPIHLS
- Characteristics
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Purified recombinant Human DSCR1 isoform b protein
Expression System: E.coli
Molecular weight on SDS-PAGE will appear higher. - Purity
- > 90 % pure
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Regulator of Calcineurin 1 (RCAN1) (AA 1-197) protein (GST tag)
RCAN1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Regulator of Calcineurin 1 (RCAN1) (AA 1-100) protein (GST tag)RCAN1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Regulator of Calcineurin 1 (RCAN1) (AA 1-252) protein (Strep Tag)Crystallography grade RCAN1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Regulator of Calcineurin 1 (RCAN1) (AA 1-198) protein (His tag)Crystallography grade RCAN1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS, Crys
Regulator of Calcineurin 1 (RCAN1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)RCAN1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- DSCR1 protein has been used in SDS PAGE and may be suitable for use in other assays to be determined by the end user.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Supplied as a liquid in 20 mM Tris, pH 7.5, containing 0.1 M NaCl, and 0 mM DTT.
- Preservative
- Dithiothreitol (DTT)
- Precaution of Use
- This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- RT/-20 °C
- Storage Comment
- Store at 4 °C for short term storage (1/2 weeks). Aliquot and store at -20 °C or - 70 °C for long term storage.
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- Target
- RCAN1 (Regulator of Calcineurin 1 (RCAN1))
- Alternative Name
- DSCR1 (RCAN1 Products)
- Synonyms
- ADAPT78 Protein, CSP1 Protein, DSC1 Protein, DSCR1 Protein, MCIP1 Protein, RCN1 Protein, RCAN1 Protein, 2410048A02Rik Protein, AA408855 Protein, AI429645 Protein, AL024459 Protein, AV028423 Protein, Adapt78 Protein, CALP1L Protein, Dscr1 Protein, Mcip1 Protein, dscr1 Protein, rcan1 Protein, wu:fr92c05 Protein, adapt78 Protein, csp1 Protein, dsc1 Protein, mcip1 Protein, MGC53636 Protein, rcn1 Protein, MGC69428 Protein, regulator of calcineurin 1 Protein, regulator of calcineurin 1b Protein, regulator of calcineurin 1 L homeolog Protein, Down syndrome critical region gene 1 Protein, RCAN1 Protein, Rcan1 Protein, rcan1b Protein, rcan1.L Protein, dscr1 Protein, rcan1 Protein
- Background
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The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. DSCR1 Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A, possibly affecting central nervous system development. DSCR isoform b is shorter at the N-terminus compared to isoform a. Recombinant human DSCR1 was expressed in E. coli and purified by using conventional chromatography techniques.
Alternative Names: DSCR1, Down syndrome candidate region 1, calcipressin 1 protein, DSCR 1, DSCR 1 protein, Down syndrome candidate region 1 protein, DSCR-1, Calcipressin 1 isoform b protein, adapt78 protein protein, Down syndrome critical region protein 1 protein, DSCR-1 protein - Molecular Weight
- 13 kDa (117 AA)
- Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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