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we identified seven new putative CCP1 substrates, all of them harboring acidic amino acids in their gene-encoded C terminus
Data indicate that a functional nuclear export signals (NESs) in CCP1 that mediates direct binding to the export receptor CRM1 (show XPO1 ELISA Kits).
Lack of Cytosolic Carboxypeptidase 1 Leads to Subfertility due to the Reduced Number of Antral Follicles in pcd3J-/- Females.
Nna1 and CCP4 remove the C-terminal glutamate (show GRIN1 ELISA Kits) from substrates with two or more glutamates, whereas CCP6 (show AGBL4 ELISA Kits) requires four or more glutamates. CCP4 behaves as a promiscuous glutamase with little preference for chain length or neighboring amino acid composition
The lack of CCP1/Nna1 leads to decreases in cellular levels of amino acids, which leads to elevated autophagy as a protective response to cellular amino acid starvation.
The nna1 deficiency demonistrated that gliosis occurring during mitral cells and Purkinje cells death in the PCD (show PCBD1 ELISA Kits) mouse.
This study characterized the structure, expression and activity of wild type and mutated Nna1 in Purkinje cell degeneration (pcd) mice.
These data indicated that serotonergic function in the MOB (show SGMS1 ELISA Kits) is closely related to olfactory activity and that mitral cell loss induces serotonergic plastic responses.
These results demonstrate a role for CCP1 (show Gzmb ELISA Kits) in the processing of Glu (show GCG ELISA Kits) residues from beta- as well as alpha-tubulin (show TUBA4A ELISA Kits) in vitro and in vivo.
Agtpbp1 plays an important role in spermatogenesis and is important for survival of germ cells at spermatocytes stage onward
Study analyzes Purkinje cell degeneration (pcd) mice that lack functional CCP1 (show Gzmb ELISA Kits) and shows that microtubule hyperglutamylation is directly linked to neurodegeneration.
This study provided insight into Nna1's role in neuronal development and why its absence renders Purkinje cells more vulnerable.
Essential roles of agtpbp1 and eps15L1 in T cell development in Danio rerio.
These data suggest that CCP1 and CCP5 (show AGBL5 ELISA Kits) play important roles in developmental processes, particularly the development and functioning of cilia.
NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.
ATP/GTP-binding protein 1
, cytosolic carboxypeptidase 1
, ATP/GTP binding protein 1
, cytosolic carboxypeptidase 1-like
, nervous system nuclear protein induced by axotomy protein 1 homolog
, soluble carboxypeptidase
, tubulinyl-Tyr carboxypeptidase
, tyrosine carboxypeptidase
, Purkinje cell degeneration
, nervous system nuclear protein induced by axotomy protein 1
, nuclear ATP/GTP-binding protein