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ATP5G1 turnover increases upon depletion of ZC3H14 (show ZC3H14 ELISA Kits), double knockdown of ZC3H14 (show ZC3H14 ELISA Kits) and the nonsense-mediated decay factor, UPF1 (show UPF1 ELISA Kits), rescues ATP5G1 transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 (show ZC3H14 ELISA Kits) is depleted and that ZC3H14 (show ZC3H14 ELISA Kits) binds to ATP5G1 pre-mRNA in the nucleus.
The subunit c isoforms are nonredundant, because they differ functionally by their targeting peptides, which, in addition to mediating mitochondrial protein (show COX6B2 ELISA Kits) import, play a yet undiscovered role in respiratory chain maintenance.
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified.
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)-like
, ATP synthase lipid-binding protein, mitochondrial
, ATP synthase H+ transporting mitochondrial F0 complex subunit c (subunit 9) isoform 1
, ATP synthase proteolipid P1
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c
, ATPase protein 9
, ATPase subunit c
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1
, ATPase subunit 9
, ATPase subunit C
, mitochondrial ATP synthase, subunit 9
, mitochondrial ATP synthase, subunit C
, mit-ATP synthase proteolipid P1 subunit
, mitochondrial ATP5G1
, mitochondrial H+ transporting ATP synthase
, H(+)-transporting ATP synthase