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We obtained correlations between Atp5g3 and alcoholism- and obesity-relevant phenotypes.
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding different proteins have been identified.
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3
, ATP synthase lipid-binding protein, mitochondrial
, ATP synthase proteolipid P3
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)
, ATPase protein 9
, ATPase subunit c
, ATP synthase subunit 9
, ATP synthase, mitochondrial, C subunit-3
, ATPase subunit C
, ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c