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Browse our anti-NNT (NNT) Antibodies

Full name:
anti-Nicotinamide Nucleotide Transhydrogenase Antibodies (NNT)
On www.antibodies-online.com are 48 Nicotinamide Nucleotide Transhydrogenase (NNT) Antibodies from 10 different suppliers available. Additionally we are shipping NNT Proteins (7) and NNT Kits (1) and many more products for this protein. A total of 64 NNT products are currently listed.
Synonyms:
4930423F13Rik, Afu5g02780, AI323702, BB168308, GCCD4, wu:fa20d10, wu:fc86a04, zgc:76979
list all antibodies Gene Name GeneID UniProt
NNT 23530 Q13423
NNT 18115  
NNT 310378  

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Most Popular Reactivities for anti-NNT (NNT) Antibodies

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anti-Human NNT Antibodies:

anti-Mouse (Murine) NNT Antibodies:

anti-Rat (Rattus) NNT Antibodies:

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Top referenced anti-NNT Antibodies

  1. Cow (Bovine) Polyclonal NNT Primary Antibody for WB - ABIN2782785 : Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005 (PubMed)

  2. Human Monoclonal NNT Primary Antibody for IF, ELISA - ABIN565110 : Picklo: Ethanol intoxication increases hepatic N-lysyl protein acetylation. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against NNT Interaction Partners

Caenorhabditis elegans (C. elegans) Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. nnt-1 is important in the defense against mitochondrial oxidative stress

Human Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. NNT should be sequenced in all primary adrenal insufficiencies for which the most frequent etiologies have been ruled out. As NNT is involved in oxidative stress, careful follow-up is needed to evaluate mineralocorticoid biosynthesis extent, and gonadal, heart and thyroid function.

  2. identified a 6.67 Mb homozygous region harboring the NNT gene in a Dutch patient presenting with familial glucocorticoid deficiency (FGD (show FGD1 Antibodies)); a novel homozygous mutation (NM_012343.3: c.1259dupG) in NNT was revealed; reviewed the literature for all the reported NNT mutations and their clinical presentation

  3. This report of a novel NNT mutation, p.G200S, expands the phenotype of NNT mutations to include mineralocorticoid deficiency. It provides the first evidence that NNT mutations can cause oxidative stress and mitochondrial defects.

  4. Data suggest mutations in nicotinamide nucleotide transhydrogenase (NNT) as contributory to left ventricular noncompaction (LVNC).

  5. NNT mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin (show INS Antibodies).

  6. Results suggest that NNT may have a role in ROS (show ROS1 Antibodies) detoxification in human adrenal glands.

  7. In the failing heart a partial loss of Nnt activity adversely impacts NADPH (show NQO1 Antibodies)-dependent enzymes and the capacity to maintain membrane potential, thus contributing to a decline in bioenergetic capacity, redox regulation and antioxidant defense.

Mouse (Murine) Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. this study demonstrates that the respiratory state and/or substrates that sustain energy metabolism markedly influence the relative contribution of NNT (i.e. varies between nearly 0 and 100%) to NADPH (show FDXR Antibodies)-dependent mitochondrial peroxide metabolism.

  2. Pathologic workload reverses Nnt to deplete NADPH (show FDXR Antibodies) and antioxidative capacity. Reverse Nnt induces mitochondrial oxidative stress and necrosis.

  3. In mitochondria, genetic or pharmacological disruptions in the PDHC-NNT redox circuit negate counterbalance changes in energy expenditure

  4. Data conclude that Herpud1 (show HERPUD1 Antibodies) regulates insulin (show INS Antibodies) secretion via control of Nnt expression.

  5. our data suggest that NNT functions as a high-capacity source of mitochondrial NADPH (show FDXR Antibodies) and that its functional loss due to the Nnt mutation results in mitochondrial redox abnormalities

  6. the role of NNT in regulating central carbon metabolism via redox balance, calling for other mechanisms that coordinate substrate preference to maintain a functional TCA cycle.

  7. Our results demonstrate a novel role for NNT as a regulator of macrophage-mediated inflammatory responses

  8. A normal Nnt allele can help with better cardiac function in MnSOD (show SOD2 Antibodies)-deficient mice during fetal development.

  9. The presence of a truncated Nnt did not affect insulin (show INS Antibodies) secretion or glucose tolerance on the C57BL/6 background.

  10. Nnt was identified as a novel candidate gene for contribution to glucose intolerance through reduced beta cell activity.

NNT Antigen Profile

Antigen Summary

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.

Alternative names and synonyms associated with NNT

  • Nicotinamide Nucleotide Transhydrogenase (nnt-1) antibody
  • nicotinamide nucleotide transhydrogenase (AFUA_5G02780) antibody
  • nicotinamide nucleotide transhydrogenase (nnt) antibody
  • nicotinamide nucleotide transhydrogenase (NNT) antibody
  • nicotinamide nucleotide transhydrogenase (Nnt) antibody
  • 4930423F13Rik antibody
  • Afu5g02780 antibody
  • AI323702 antibody
  • BB168308 antibody
  • GCCD4 antibody
  • wu:fa20d10 antibody
  • wu:fc86a04 antibody
  • zgc:76979 antibody

Protein level used designations for NNT

Nicotinamide Nucleotide Transhydrogenase family member (nnt-1) , nicotinamide nucleotide transhydrogenase , NAD(P) transhydrogenase, mitochondrial , pyridine nucleotide transhydrogenase , Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)

GENE ID SPECIES
180884 Caenorhabditis elegans
3505502 Aspergillus fumigatus Af293
100158572 Xenopus (Silurana) tropicalis
23530 Homo sapiens
18115 Mus musculus
310378 Rattus norvegicus
406619 Danio rerio
447528 Xenopus laevis
427196 Gallus gallus
280878 Bos taurus
479342 Canis lupus familiaris
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