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Increased expression of cerebral UCP5 and UCP4 (show SLC25A27 Antibodies) is observed in a model of high altitude hypoxia and mitochondrial oxidative phosphorylation deficiency.
Compares and contrasts all the known human SLC25A (show SLC25A25 Antibodies)* genes and includes functional information.
Neuronal UCP5 exhibits transmembrane chloride transport activity.
observed significant associations between genetic variants in the SIRT6 (show SIRT6 Antibodies) and UCP5 genes and atherosclerotic plaque
The enhanced level of UCP5 is associated to mitochondrial dysfunction in colonic cells.
expressed in skeletal muscle as three different isoforms; expression level of UCP5SI positively correlated with resting metabolic rate and lipid oxidation rate during a euglycemic clamp (show PDZK1 Antibodies) with infusion of insulin (show INS Antibodies) at a physiologic concentration
UCP5 might be physiologically important in the pathology of oxidative stress-induced (show SQSTM1 Antibodies) neurodegeneration
These findings suggest that UCP2 (show UCP2 Antibodies) and UCP4 (show SLC25A27 Antibodies) have a modest but important involvement in the genetic etiology of schizophrenia.
The brain may respond to neuroprotection through the increased expression of UCP5 under ischemic conditions.
These results suggest that UCP4 (show SLC25A27 Antibodies) and BMCP1 are regulated by insulin (show INS Antibodies) and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby may play an important role in lipid and energy metabolism.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene.
brain mitochondrial carrier protein 1
, solute carrier family 25, member 14
, solute carrier family 25 (mitochondrial carrier, brain), member 14
, mitochondrial uncoupling protein 5
, uncoupling protein 5
, UCP 5
, solute carrier family 25 member 14