MYST1 antibody

Catalog No. ABIN1724671

Product Details anti-MYST1 Antibody

Target: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYST1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purification: purified

Immunogen: Purified recombinant fragment of human MYST1 expressed in E. coli.

Clone: 8C4C4

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References for anti-MYST1 antibody (ABIN1724671)

Jiang, Gao, Zheng, Yin, Wang, Zhong, Ali, Khan, Hao, Fang, Sun, Xu, Pandita, Jiang, Shi: "MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice." in: PLoS genetics, Vol. 14, Issue 5, pp. e1007300, (2018) (PubMed).

Akhtar, Becker: "The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition." in: EMBO reports, Vol. 2, Issue 2, pp. 113-8, (2001) (PubMed).

Neal, Pannuti, Smith, Lucchesi: "A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF." in: Biochimica et biophysica acta, Vol. 1490, Issue 1-2, pp. 170-4, (2000) (PubMed).

Sterner, Berger: "Acetylation of histones and transcription-related factors." in: Microbiology and molecular biology reviews : MMBR, Vol. 64, Issue 2, pp. 435-59, (2000) (PubMed).

Target Details for MYST1

Target: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Alternative Name: MYST1 (KAT8 Products)

Synonyms: myst1 antibody, wu:fb22g02 antibody, wu:fj22d09 antibody, zgc:66387 antibody, Myst1 antibody, MOF antibody, MYST1 antibody, ZC2HC8 antibody, hMOF antibody, 2010203C02Rik antibody, 5830450F21Rik antibody, D7Ertd629e antibody, K(lysine) acetyltransferase 8 antibody, lysine acetyltransferase 8 antibody, kat8 antibody, KAT8 antibody, Kat8 antibody

Background:

Description: MYST1 (MYST histone acetyltransferase 1, MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone

Aliases: MOF, KAT8, hMOF

Molecular Weight: 53 kDa

Gene ID: 84148

HGNC: 84148